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Overview
The basic phenomena of intra- and intercellular communication and the transport signals within and between the cells controlling cardiac function are described and discussed in this volume. The amazing synchronization of millions of cells and billions of nanoscale molecular motors, ion gates, and ion pumps assure normal cardiac function; whereas disharmony and local transport and signal disruptions are the forecasters, and eventual causes, of pathologic conditions and heart failure.
Although this volume concentrates on basic phenomena, strong emphasis is given to the related clinical and pharmaceutical manifestations, and chapters have been contributed by molecular biologists, pharmaceutical experts, and cardiac scientists.
This volume will promote better understanding and, consequently, better clinical and pharmaceutical handling of the various aspects of cardiac pathophysiologies associated with electrical, mechanical, and metabolic and circulatory disorders in the cardiovascular system.
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Synopsis
In these papers from the June 2005 workshop, contributors describe their research in intercellular and intracellular ionic and molecular communications. Topics include cardiac cell development, calcium signaling, energetics and transport, electromechanical interactions and modeling, novel therapeutics for the failing and arrhythmogenic cardiac cell, a preview of future research, and reviews of the cellular communication maze and the steps and their consequences from organ to molecule. Individual topics include the evolution of the heart from bacteria to humans, modification of cellular communication by gene transfer, and cardiac systems biology. Annotation ©2005 Book News, Inc., Portland, OR