Scientific Computing, Biology - Molecular Biology, Biochemistry - Amino Acids, Biochemistry - Proteins - General & Miscellaneous
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Overview
Sequence data—either lists of nucleotides or of amino acids—are now easily gathered using automated equipment; the real effort is involved in interpreting the data to produce predictions of protein structure or function. With the advent of worldwide computer networks, a plethora of software is now available for sequence analysis. This book describes the techniques for computer analysis of sequence data, with the emphasis on general issues rather than specific algorithms. Unlike many books on these topics, which focus on the "how-to" aspects of software packages, this one places more emphasis on the science behind the packages and on interpretation of the results.
The book contains predominantly black-and-white illustrations, with some color illustrations.
Editorials
Philip M. Sass
This well-thought-out and well-written book covers the complex and constantly changing field of molecular databases. The purpose is to provide a sourcebook of molecular biology databases and to demonstrate some conclusions that can be drawn from analyzing sequence information. It is written for any biologist who wishes to access DNA sequence information to study structure/function or evolutionary relationships. The book is directed at the molecular biology researcher as well as at other biologists who wish to access this information. The book contains a thorough introduction to the core problem: the bewildering number of databases and sequence information they contain, which is growing exponentially. Next, the book describes several software tools, such as Entrez, Blast, and dbEST. A description of how to access the NCBI database, which contains a wealth of information, including GenBank, is included. This book also contains several very good chapters on DNA sequencing methodology software and an excellent chapter on molecular biology software for Macintosh. Finally, a series of chapters illustrate, with specific examples, how to access and find specific databases to predict mRNA sequence structure, find specific DNA or protein motifs in a DNA or protein of interest, and determine function and evolutionary relationships among families of related proteins. These chapters will appeal particularly to those scientists interested in using database information to study a particular aspect of their gene of interest. I would highly recommend this book to libraries as a resource book and to scientists who need to access molecular biology databases.Reviewer: Philip M. Sass, PhD(University of Illinois at Chicago College of Medicine)
Description: This well-thought-out and well-written book covers the complex and constantly changing field of molecular databases.
Purpose: The purpose is to provide a sourcebook of molecular biology databases and to demonstrate some conclusions that can be drawn from analyzing sequence information.
Audience: It is written for any biologist who wishes to access DNA sequence information to study structure/function or evolutionary relationships. The book is directed at the molecular biology researcher as well as at other biologists who wish to access this information.
Features: The book contains a thorough introduction to the core problem: the bewildering number of databases and sequence information they contain, which is growing exponentially. Next, the book describes several software tools, such as Entrez, Blast, and dbEST. A description of how to access the NCBI database, which contains a wealth of information, including GenBank, is included. This book also contains several very good chapters on DNA sequencing methodology software and an excellent chapter on molecular biology software for Macintosh. Finally, a series of chapters illustrate, with specific examples, how to access and find specific databases to predict mRNA sequence structure, find specific DNA or protein motifs in a DNA or protein of interest, and determine function and evolutionary relationships among families of related proteins. These chapters will appeal particularly to those scientists interested in using database information to study a particular aspect of their gene of interest.
Assessment: I would highly recommend this book to libraries as a resource book and to scientists who need to access molecular biology databases.
4 Stars! from Doody
Book Details
Published
January 30, 1997
Publisher
Oxford University Press, USA
Pages
376
Format
Paperback
ISBN
9780199634637