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Overview
Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attention to inherited gene lesions. With contributions from a panel of international experts, this volume provides an accessible, up-to-date overview of modern steroid biology for both the professional and novice researcher alike.
Synopsis
Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attention to inherited gene lesions. With contributions from a panel of international experts, this volume provides an accessible, up-to-date overview of modern steroid biology for both the professional and novice researcher alike.
Doody Review Services
Reviewer:Catherine Pihoker, MD(University of Washington School of Medicine)
Description:This book, a volume in the Modern Genetics series, is intended to provide up-to-date information on steroid synthesis and function.
Purpose:Tissue-specific structure, function, and regulation of steroid enzymes and the genes encoding the enzymes are presented. The book covers molecular genetics of impaired steroidgenesis and pharmacological action of steroids and agents affecting steroid synthesis and action.
Audience:The audience for the Modern Genetics series includes researchers and clinicians. As such, this volume ambitiously includes material in animal models and humans. The book assumes readers have a solid understanding of steroid action and molecular genetics. Clinical situations resulting from mutations are presented with brief descriptions of normal findings as well as the physiological changes resulting from the mutations. Recognized authorities have contributed to this book. Their expertise and recent contributions to the field are evident.
Features:Multiple aspects of steroid metabolism are addressed. Studies in animals and humans are included, as well as clinical scenarios exemplifying abnormal steroidgenesis. In some chapters the genetic studies referenced alternate between animal an human models, without clarity as to whether a finding refers to animal or human. Format and use of illustrations or tables varies from one chapter to the next. More consistent use of figures would complement some of the text. References are consistently up-to-date and include material that serves as the backbone of understanding.
Assessment:This book contains interesting, up-to-date material dealing with many aspects of steroid metabolism. The selection of material is likely to be helpful to a wide audience. The book ambitiously bridges the basic research and clinical realms of the field. Material that may provide additional background to readers less familiar with a particular field is lacking in parts; usually recent informative references are provided.
Editorials
From The Critics
Reviewer: Catherine Pihoker, MD(University of Washington School of Medicine)Description: This book, a volume in the Modern Genetics series, is intended to provide up-to-date information on steroid synthesis and function.
Purpose: Tissue-specific structure, function, and regulation of steroid enzymes and the genes encoding the enzymes are presented. The book covers molecular genetics of impaired steroidgenesis and pharmacological action of steroids and agents affecting steroid synthesis and action.
Audience: The audience for the Modern Genetics series includes researchers and clinicians. As such, this volume ambitiously includes material in animal models and humans. The book assumes readers have a solid understanding of steroid action and molecular genetics. Clinical situations resulting from mutations are presented with brief descriptions of normal findings as well as the physiological changes resulting from the mutations. Recognized authorities have contributed to this book. Their expertise and recent contributions to the field are evident.
Features: Multiple aspects of steroid metabolism are addressed. Studies in animals and humans are included, as well as clinical scenarios exemplifying abnormal steroidgenesis. In some chapters the genetic studies referenced alternate between animal an human models, without clarity as to whether a finding refers to animal or human. Format and use of illustrations or tables varies from one chapter to the next. More consistent use of figures would complement some of the text. References are consistently up-to-date and include material that serves as the backbone of understanding.
Assessment: This book contains interesting, up-to-date material dealing with many aspects of steroid metabolism. The selection of material is likely to be helpful to a wide audience. The book ambitiously bridges the basic research and clinical realms of the field. Material that may provide additional background to readers less familiar with a particular field is lacking in parts; usually recent informative references are provided.
3 Stars from Doody