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Synopsis
With the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteomics: Methods and Protocols, experts in the neurological and analytical sciences present experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. Divided into four convenient sections, this collection covers CNS animal models used for neuroproteomics research, methods for separating and analyzing discrete subcomponents of the neuroproteome, large-scale approaches for CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Neuroproteomics: Methods and Protocols includes the clear “how-to” information needed to critically assess what can be accomplished in the field and how to best perform and evaluate neuroproteomic experiments in one’s own research.
Doody Review Services
Reviewer:Omer Iqbal, MD, FACC, FESC(Loyola University Medical Center)
Description:This book provides experimental details about animal models for neuroproteomic research, methods for separating and analyzing discrete subcomponents of the neuroproteome, and CNS proteome characterization and quantification, as well as methods that evaluate biofluids and translate neuroproteomic results into clinical platforms.
Purpose:The purpose is to provide an account of tools used by researchers to address questions in neuroscience.
Audience:The authors intend the book for basic and clinical researchers, and it will be of much interest to basic scientists, clinical scientists, and students interested in applying proteomics to the neurosciences.
Features:Part I of the book's four parts deals with animal models used for neuroproteomics research. Part II covers the methods for separating the neuroproteome and analyzing select discrete components, while part III covers large-scale approaches for CNS proteome characterization. Part IV details methods that evaluate biofluids and translate neuroproteomic results into clinical platforms. The book is well illustrated and each chapter includes a brief introduction, lists of the necessary materials and reagents, laboratory protocols, and notes on troubleshooting and how to avoid known pitfalls.
Assessment:This is a valuable resource for basic scientists and clinical scientists in the field of neuroproteomics. Students who are interested in applying proteomics to the neurosciences also will find this book very helpful.