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Synopsis
Lutz, Howard M. Prentice (both Florida Atlantic U.) and Gören E. Nilsson (U. of Oslo, Norway) describe the physiological systems that promote brain survival in the absence of oxygen in anoxia tolerant species, and compare them with the processes that occur in mammalian brains during the initial few minutes of asphyxiation when anoxia is combated, and with the degenerative changes that occur during the subsequent anoxic failure. They are most interested in the processes underlying the suppression of metabolic and functional activities to new set points well below their normoxic minima or maintenance levels. Their hope is that studies using anoxia tolerant species as models will help identify potential targets for human clinical intervention. Annotation (c)2003 Book News, Inc., Portland, OR