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Synopsis
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans.
Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Lisa Boggio
This book discusses angiogenesis, agents that inhibit angiogenesis, and the clinical design and application of anti-angiogenic agents. It takes stock of what has been accomplished in angiogenesis research, the future anti-angiogenic therapeutic agents, and the methods of new drug generation. This book is written for researchers in the field of angiogenesis and those interested in the mechanisms of angiogenesis and its inhibition. Since angiogenesis is involved in all organ functions, experts in many fields of medical research will find this useful. The contributors in this volume are well known in the field of angiogenesis. It is divided into three sections: a discussion of factors which regulate the formation of blood vessels to tumors; agents and cytokines which have been shown to have activity inhibiting blood vessel formation; and drugs which have been used in clinical trials. This book is hampered by several typographical errors which at times make the text confusing for those who are not familiar with the topic. Often, the difficulty in writing a book of this type is that new information is being developed all the time and books quickly become outdated. Presenting the basic tenets of angiogenesis and anti-angiogenic therapy averts this problem and makes this a useful resource.