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Overview
This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and effector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature of the molecules that will either constitute targets for future drugs or influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis. By focusing on essential questions and critically summarizing the overwhelming tide of recent research results, Apoptosis and Cancer Chemotherapy illuminates not only the potential targets for tumor therapy, but beyond that, potential control points for cancer and such diverse diseases as viral infection, neurodegenerative disorders, and stroke. This collection of cutting-edge reviews by established leaders in the field critically summarizes the recent discoveries concerning apoptosis, cell suicide. The book looks forward to the time when such cell death can be controlled to treat cancer and a host of other diseases as diverse as viral infection, neurodegenerative disorders, and stroke.
The book contains black-and-white illustrations.
The realization that responses of tumors to chemotherapy also depends on so-called “downstream” events has created much interest in regulators of apoptosis as determinants of drug action. And, because these regulators also play key roles in multistage carcinogenesis, they provide important potential targets for new therapies. Acknowledged leaders in the field have written thoughtful and up-to-date reviews, as well as personal views of some of the conundrums facing the field, such as finding the prognostic value of molecules like p53 and bcl-2 in determining responses to therapies and how these molecules function in different cellular contexts. This series of short reviews, with prioritized reading recommendations, presents a contemplative assessment of the field.