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Overview
Bone and Cartilage Engineering presents the theory and practice of cell-based regeneration of skeletal defects. Much of the focus is on the importance of the cell biological and biomaterial aspects for engineering a clinically relevant device. The basic key techniques for optimal engineering outcomes including cell and organ culture, biomaterial development, and bioreactor use are described in detail and highlighted by multiple figures. Cell-matrix and cell-biomaterial interactions are discussed for evaluating different tissue engineering strategies. Focusing also on preclinical models, clinical applications, ethical, and regulatory issues, this book provides state-of-the-art information on cell-based skeletal tissue engineering.Synopsis
Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.
Editorials
From The Critics
Reviewer: Mark R Hutchinson, MD(University of Illinois at Chicago College of Medicine)Description: This book presents the theory and practice of cell-based regeneration of skeletal defects ranging from bone to cartilage. The authors quickly advance past foundational information to the current state-of-the-art in the various aspects of regeneration technology including information on principles of bone and cartilage repair strategies, stem cells, scaffold fabrication, biorectors and tissue engineering.
Purpose: The authors hope this book will serve as a foundation and stimulus for basic researchers and clinicians involved in the investigation and application of tissue engineering in clinical practice, and contribute to making bone and cartilage engineering an attractive and reliable alternative treatment option in reconstructive surgery.
Audience: With the relative paucity of similar, current books in the field, the authors have done a solid job of creating a book that will be read by residents, clinicians, and researchers alike.
Features: The authors move from foundational basics to advanced and future concepts of bioengineering of bone and cartilage in this concise, well written book. It is logically organized into areas focusing on bone, cartilage, research issues, and clinical applications. The best feature of this book is that it collects all of the current information into one tightly organized book. It also includes helpful figures and an extended reference list at the end. A potential shortcoming is that in a field so fluid and constantly changing, much of the information could be out of date in 2 to 5 years.
Assessment: This is a valuable contribution to the field. It is an advantage to have such an organized, well written, concise publication on this topic available at your fingertips. All clinicians who practice cartilage reconstruction will find it a valuable read and orthopedic libraries will find it a valuable addition to their book list.