Synopsis
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis.
This fourth edition:
- Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
- Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis
- Includes new diagnostic algorithms and summary boxes
- Contains 550 colour illustrations including high-quality digital photomicrographs
Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.
Doody Review Services
Reviewer:Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description:This comprehensive book on bone marrow pathology updates the 2001 edition.
Purpose:The purpose is to provide a practical guide to bone marrow interpretation that integrates peripheral blood and bone marrow aspirate findings.
Audience:The book is intended for "haematologists and histopathologists," British terminology for clinical hematologists and pathologists (including hematopathologists) in the U.S. It also would be useful for pathology or laboratory medicine residents, hematopathology fellows, clinical hematology fellows, or medical students with a special interest in hematology/hematopathology. The authors are recognized international experts in this field.
Features:This is a really wonderful book for hematopathologists, and this edition is updated to incorporate the 2008 WHO hematological disease classifications. The field is rapidly changing and expanding in both immunophenotyping and genetic testing, making this update very welcome. Although the book has only 11 chapters, each one is substantial, detailed, comprehensive, and quite lengthy (e.g., the chapters on lymphoproliferative disorders, acute leukemia, and myeloproliferative/myelodysplastic neoplasms are 121, 71 and 61 pages, respectively). What I really like is the seamless integration of peripheral blood and bone marrow aspirate findings into the complete bone marrow interpretation. In this regard, the book nicely bridges a common gap in today's bone marrow interpretation, where clinical hematologists interpret peripheral blood and bone marrow aspirate smears, and pathologists typically focus predominantly on histology specimens with imperfect correlation between disciplines. I also like the section on problems and pitfalls in each chapter, educating readers about mistakes to avoid. My only less than enthusiastic comment regards the less than perfect color compensation of the photomicrographs. Many have yellow (instead of white) backgrounds and there is variable (instead of standardized) RBC color between photomicrographs. Even though the color compensation is not perfect, the displays of pathognomonic examples are priceless.
Assessment:This is one of only a few references that effortlessly integrate the entire process critical for accurate bone marrow interpretation. It is a must for practicing hematopathologists.