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Overview
Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available.
Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage.
A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.
Synopsis
Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available.
Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage.
A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.
Doody Review Services
Reviewer:John Buchholz, PhD(Loma Linda University)
Description:Carbon monoxide (CO) is an odorless, colorless gas that is abundant in air pollutants and cigarette smoke. Exposure to CO has many documented cardiovascular effects. However, recently it has been shown that CO may be produced via normal metabolic processes such as lipid peroxidation. This book is an overview of the importance of CO as an agent that modulates cardiovascular function. It includes a complete summary on its formation in vivo to the effects on smooth muscle tone.
Purpose:The purpose is to provide concise, up-to-date reviews of the fundamentals on the biological actions of CO. These are notable and worthy objectives as CO, both as a metabolite and environmental pollutant, cannot be ignored. The book has surpassed the author's objectives.
Audience:This book is written for the more sophisticated scientist in the area of cardiovascular physiology and pharmacology. The book would also be useful as a graduate text. The author is a well recognized cardiovascular scientist.
Features:The book covers a broad spectrum from the physiological actions of CO on the cardiovascular system to its possible role in hypertension. What is best about the book is the discussion of the role of CO in vascular function that in turn allowed for the discovery of deficiencies in the hemo oxygenase genes and alterations in vascular function.
Assessment:The book gives a first rate summary of the mechanisms by which CO exerts its action on vascular smooth muscle. The chapters can be best described as review chapters summarizing important advances in the basic science of CO and its probable role in cardiovascular function. The illustrations and pertinent data are well organized and clear. The book is a good source for graduate or upper division undergraduate courses in pharmacology, physiology or biochemistry of CO. To my knowledge there are no other books on this subject.
Editorials
From The Critics
Reviewer: John Buchholz, PhD(Loma Linda University)Description: Carbon monoxide (CO) is an odorless, colorless gas that is abundant in air pollutants and cigarette smoke. Exposure to CO has many documented cardiovascular effects. However, recently it has been shown that CO may be produced via normal metabolic processes such as lipid peroxidation. This book is an overview of the importance of CO as an agent that modulates cardiovascular function. It includes a complete summary on its formation in vivo to the effects on smooth muscle tone.
Purpose: The purpose is to provide concise, up-to-date reviews of the fundamentals on the biological actions of CO. These are notable and worthy objectives as CO, both as a metabolite and environmental pollutant, cannot be ignored. The book has surpassed the author's objectives.
Audience: This book is written for the more sophisticated scientist in the area of cardiovascular physiology and pharmacology. The book would also be useful as a graduate text. The author is a well recognized cardiovascular scientist.
Features: "The book covers a broad spectrum from the physiological actions of CO on the cardiovascular system to its possible role in hypertension. What is best about the book is the discussion of the role of CO in vascular function that in turn allowed for the discovery of deficiencies in the hemo oxygenase genes and alterations in vascular function. "
Assessment: "The book gives a first rate summary of the mechanisms by which CO exerts its action on vascular smooth muscle. The chapters can be best described as review chapters summarizing important advances in the basic science of CO and its probable role in cardiovascular function. The illustrations and pertinent data are well organized and clear. The book is a good source for graduate or upper division undergraduate courses in pharmacology, physiology or biochemistry of CO. To my knowledge there are no other books on this subject. "
From The Critics
Most readers would expect a short book on the subject, characterized mainly by a red circle with a slash through it. Scientists, however, have delved into the physiological mechanisms of carbon monoxide, and have gradually changed its status from a purely toxic gas to a dual- function compound involved in the homeostatic control of cardiovascular functions. They explain the mechanisms of the gas' actions with practical approaches to studying its biological roles under different conditions, and discuss a number of disorders in which its cardiovascular effects are suspected to have been altered, among them hypertension, diabetes, inflammation, and ischemic heart damage. Annotation c. Book News, Inc., Portland, OR (booknews.com)3 Stars from Doody