Catalysts For Fine Chemical Sy

The chemist has a vast range of high-tech catalysts to use when working in fine chemical synthesis but the catalysts are generally hard to use and require both time, skill and experience to handle properly. The Catalysts for Fine Chemical Synthesis series contains tested and validated procedures which provide a unique range resources for chemists who work in organic chemistry.

"... of great value to synthetic organic chemists..." (The Chemists, Summer 2003)

Volume 3 in the series focuses on catalysts for carbon-carbon bond formation and presents practical  and detailed protocols on how to use sophisticated catalysts by the "inventors" and "developers" who created them. The combination of protocols and review commentaries helps the reader to easily and quickly understand and use the new high-tech catalysts.

Catalysts are increasingly used by chemists working in fine chemical synthesis in industry and academia. Today, there exists a huge choice of high-tech catalysts, which add enormously to the repertoire of synthetic possibilities. However, catalysts are tricky to use and require both skill and experience in order to achieve optimal results.

This Series wants to be a practical help for advanced undergraduate, graduate and postgraduate students, and chemists in industry and academia working in organic and organometallic synthesis.

The Series features:

• Tested and validated procedures

• Authorative reviews on classes of catalysts

• Assessments of all types of catalysts

• The expertise from the Leverhulme Centre for Innovative Catalysis, Liverpool, UK.

The formation of Carbon-Carbon bonds is one of the most important transformations used in the synthesis of fine chemicals. Catalysts promoting such transformations are in ever increasing demand.

In this book the reader will find worked examples of a selection of Carbon-Carbon bond forming reactions including the asymmetric alkylation of aldehydes and ketones, the Michael and Pauson-Khand reactions, aldol protocols as well as hydroformylation and carboxylation. In addition to these well-established transformations, examples of relatively new methodologies are described, for example catalysts for olefin metathesis in organic synthesis are well represented. Furthermore in the light of the popularity of palladium-catalysed coupling reactions, some of the important Heck, Suzuki and Sonogashira catalysts are described in detail and their uses exemplified.

In all chapters the preparative methods are accompanied by hints, tips and comments; safety issues are noted where appropriate.

Booknews

Reviews natural and non-natural catalysts for hydrolysis, oxidation, reduction, and carbon-carbon bond forming reactions leading to optically active products. The 13 chapters describe methods for asymmetric epoxidation of alkenes, asymmetric hydroxylation, asymmetric reduction of ketones, and asymmetric hydrogenation of carbon-carbon double bonds. For most of the reactions, there are several protocols on how to prepare and employ various catalysts, such as chiral modified diethylzinc, sulfoximine, and amino acid anions. Most of the protocols deal with non-natural catalysts because the corresponding biological procedures are featured in the sister volume, Preparative Biotransformations. Annotation c. Book News, Inc., Portland, OR