Chemistry - General and miscellaneous, Analytical Chemistry

Chiral Separations

Name: Chiral Separations
Author: D. Stevenson
ISBN: 9781461566366

by D. Stevenson, I.D. Wilson

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Synopsis

This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.

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Examines the use of light refraction to distinguish "righthand" and "lefthand" forms of otherwise identical molecules. The two forms, and mixtures of them, can have very different effects on biological functions. The research is most applicable in evaluating the safety of drugs and pesticides. The 16 papers report on the analysis of various compounds by various light sources, and describe established and experimental procedures. Includes an extensive bibliography, good cross-referencing, and abstracts of over a dozen more articles. Annotation c. Book News, Inc., Portland, OR (booknews.com)