Computer Analysis of Sequence Data, Vol. 24

These comprehensive, up-to-date handbooks are designed for those scientists engaged in the computer analysis of sequence data who want hands-on help in using the most important commercial software available, but simply do not have the time to become computer experts. The expert authors guide you through the programs with easy-to-follow, step-by-step instructions. The topics covered include translations of sequences, sequence alignment, phylogenetic trees, analysis of RNA secondary structure, database searching, submission of data to EMBL/GenBank/DDBJ/etc., maintaining sequence projects, and using patterns to analyze protein sequences.

Many chapters have been written by world-class authorities in the field, among them R. Staden, M. Gribskov, D. Higgins, W. Pearson, M. Zuker, and G. Barton. Each volume shares five essential chapters concerning the analysis of sequence data, the FASTA program, converting between sequence formats, obtaining software via INTERNET, and the submission of nucleotide sequence data.

Part I covers GCG, MicroGenie, PC/GENE, and FASTA programs.

Part II covers Staden and Staden Plus, DNA Strider, FASTA, and MacVector programs.

James M. Kramer

This book describes the use of computer programs contained in three protein/nucleic acid sequence analysis software packages: GCG, MicroGenie, and PC/GENE. Additionally, use of the FASTA program and methods for submission of sequences to the EMBL databank are described. The purpose of this book is to serve as a practical aid for scientists performing computer analyses of protein and/or nucleic acid sequences with these programs. It will help new users learn the programs more quickly and provides useful tips for experienced users. The book is targeted at scientists involved in nucleic acid/protein sequence analysis, and who already have basic knowledge of the biology of these molecules. It will be particularly useful for those with little experience using these computer programs, but also contains information that experienced users will appreciate. The multiple authors are all acknowledged experts in the field of computer sequence analysis. Step-by-step descriptions of how to use the computer programs are provided. Several examples of output from the programs are presented as figures. Solutions to some problems commonly encountered with each program are provided. This is a very useful book for all researchers involved in computer analysis of protein and/or nucleic acid sequences. It collects in one place the basic procedures for use of these computer programs that will aid inexperienced users. It also provides details of the programs that will be valuable to experienced users.

Griffin, Annette M. (Norwich Research Park); Griffin, Hugh G. (Norwich Research Park)

The contributors represent the specialties of biology, cancer research, and food and nutrition research. They come from the U.K., Germany, U.S. and Switzerland. Institutions prominently represented include Institute of Cancer Research-U.K., Institute of Food Research-U.K., Norwich Research Park-U.K., and the Virginia Polytechnic Institute and State Univ.