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Synopsis
Drug Development: Molecular Targets for GI Diseases provides a comprehensive review of contemporary molecular pharmacology approaches to discovering and developing new drugs for the prevention and treatment of gastrointestinal and liver diseases. A group of world renown and extensively published scientists in GI research provide an extensive background and new ideas on GI pharmacology. The approach of this book is unique, in that each chapter is divided into three sections, which include up to date, specific information about past, current and potential future research approaches, at the molecular level, to the introduction and use of drugs for GI diseases in that particular area of research.
Booknews
Reviews the latest research in promising areas of gastrointestinal pharmacology at the molecular level. Chapters discuss major themes including cyclooxygenase-2 inhibitors, nitric oxide pathways in the gut, influences of cytokines on inflammatory bowel disease, and new opportunities for pharmacotherapy, including peptide growth factors and serotonin. Also examined are potentials of opioid receptors in the gut as possible sites for treating motility disorders and visceral pain, and H3-receptor agonists for treating gut inflammation and pain. Gaginella is affiliated with the school of pharmacy at the University of Wisconsin-Madison. Guglietta is affiliated with Parke-Davis Pharmaceutical Research Division. Annotation c. Book News, Inc., Portland, OR (booknews.com)