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Overview
Enzyme Kinetics and Mechanism is a comprehensive textbook on steady-state enzyme kinetics. Organized according to the experimental process, the text covers kinetic mechanism, relative rates of steps along the reaction pathway, and chemical mechanism—including acid-base chemistry and transition state structure.
Practical examples taken from the literature demonstrate theory throughout. The book also features numerous general experimental protocols and how-to explanations for interpreting kinetic data.
Written in clear, accessible language, the book will enable graduate students well-versed in biochemistry to understand and describe data at the fundamental level. Enzymologists and molecular biologists will find the text a useful reference.
Synopsis
Enzyme Kinetics and Mechanism is a comprehensive textbook on steady-state enzyme kinetics. Organized according to the experimental process, the text covers kinetic mechanism, relative rates of steps along the reaction pathway, and chemical mechanism—including acid-base chemistry and transition state structure.
Practical examples taken from the literature demonstrate theory throughout. The book also features numerous general experimental protocols and how-to explanations for interpreting kinetic data.
Written in clear, accessible language, the book will enable graduate students well-versed in biochemistry to understand and describe data at the fundamental level. Enzymologists and molecular biologists will find the text a useful reference.
Doody Review Services
Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description:This definitive book on enzyme kinetics explores essentially every possible mechanism with full mathematical treatment.
Purpose:The goal is to provide a thorough and detailed analysis of enzyme kinetic behavior and the use of kinetic approaches to elucidate mechanisms. The objective is important and the solution provided by the authors complete.
Audience:The target audience includes any scientist needing to understand the kinetic behavior of an enzyme or wishing to use kinetics to study possible mechanisms of inhibitor action. The authors are leading authorities.
Features:At first glance, the heavily mathematical approaches may cause apprehension in some readers. Nevertheless, those wishing to understand their favorite enzyme will profit from this book. The treatment proceeds in logical fashion beginning with simple mechanisms (Michaelis-Menten) and moving to more complex. Isotope and pH effects are analyzed and there is a detailed discussion of inhibitors. General texts simply do not provide a comparable treatment of this area and the investigator may miss important aspects of a given enzyme's behavior. Since many drugs function as inhibitors of specific enzymatic reactions, a complete understanding of kinetics is a valuable asset in studying such interactions. There are ample references to both the primary literature and selected books.
Assessment:The leading practitioner of our time (Cleland) has produced a complete treatment of kinetic issues relating to enzymes. This is a valuable reference that also can serve an instructional role.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This definitive book on enzyme kinetics explores essentially every possible mechanism with full mathematical treatment.
Purpose: The goal is to provide a thorough and detailed analysis of enzyme kinetic behavior and the use of kinetic approaches to elucidate mechanisms. The objective is important and the solution provided by the authors complete.
Audience: The target audience includes any scientist needing to understand the kinetic behavior of an enzyme or wishing to use kinetics to study possible mechanisms of inhibitor action. The authors are leading authorities.
Features: At first glance, the heavily mathematical approaches may cause apprehension in some readers. Nevertheless, those wishing to understand their favorite enzyme will profit from this book. The treatment proceeds in logical fashion beginning with simple mechanisms (Michaelis-Menten) and moving to more complex. Isotope and pH effects are analyzed and there is a detailed discussion of inhibitors. General texts simply do not provide a comparable treatment of this area and the investigator may miss important aspects of a given enzyme's behavior. Since many drugs function as inhibitors of specific enzymatic reactions, a complete understanding of kinetics is a valuable asset in studying such interactions. There are ample references to both the primary literature and selected books.
Assessment: The leading practitioner of our time (Cleland) has produced a complete treatment of kinetic issues relating to enzymes. This is a valuable reference that also can serve an instructional role.