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Overview
In the past decade, combinatorial and high throughput experimental methods have revolutionized the pharmaceutical industry, allowing researchers to conduct more experiments in a week than was previously possible in a year. Now high throughput experimentation is rapidly spreading from its origins in the pharmaceutical world to larger industrial research establishments such as GE and DuPont, and even to smaller companies and universities. Consequently, researchers need to know the kinds of problems, desired outcomes, and appropriate patterns for these new strategies. Editor James Cawse’s far-reaching study identifies and applies, with specific examples, these important new principles and techniques.
Experimental Design for Combinatorial and High Throughput Materials Development progresses from methods that are now standard, such as gradient arrays, to mathematical developments that are breaking new ground. The former will be particularly useful to researchers entering the field, while the latter should inspire and challenge advanced practitioners. The book’s contents are contributed by leading researchers in their respective fields. Chapters include:
-High Throughput Synthetic Approaches for the Investigation of Inorganic Phase Space
-Combinatorial Mapping of Polymer Blends Phase Behavior
-Split-Plot Designs
-Artificial Neural Networks in Catalyst Development
-The Monte Carlo Approach to Library Design and Redesign
This book also contains over 200 useful charts and drawings. Industrial chemists, chemical engineers, materials scientists, and physicists working in combinatorial and high throughput chemistry will find James Cawse’s study to be an invaluable resource.
Synopsis
Researchers from the US and Europe describe what they consider the best approaches currently being used to design experiments using the two methods to develop new materials. They deal mostly with exploratory experiments, because confirmatory and optimization experiments can generally be handled with convention methods for designing experiments. They begin with methods that are now standard, such as gradient arrays, that would interest new researchers in the field, and progress to recent mathematical developments for advanced practitioners. Annotation c. Book News, Inc., Portland, OR
Editorials
From Barnes & Noble
The Barnes & Noble ReviewA new idea can change the world. Take the idea of combinatorial and high throughput experimental (CHTE) methods that were developed and applied to the pharmaceutical world in the last decade of the 20th century. That idea, modified and developed for the materials scientist, is breaking new ground. Editor James N. Cawse's book explains these methods in depth and points out how to plan and design the experiments effectively.
The book contains a selection of the best experimental design approaches in use or under development for CHTE programs. This book deals exclusively with large exploratory experiments, progressing from methods that are now standard, such as gradient arrays, to cutting-edge mathematical developments. The earlier chapters are useful to researchers entering the field, while the later chapters inspire and challenge advanced practitioners. Moreover, the book is helpful for the entire array of materials scientists -- such as catalyst chemists, metallurgists, solid-state materials specialists, and mathematicians -- that work with them.
The world is changing much more rapidly as a result of combinatorial and high throughput experimental methods. If you are to make the most of these methods, you must be able to plan your experiments effectively. This book will help you learn how to do that. John Vacca
John Vacca, the former computer security official (CSO) for NASA's space station program (Freedom), has written 38 books about advanced storage, computer security, and aerospace technology.
From the Publisher
"This book is a must for everybody interested in high-throughput experimentation." (Materials Today, October 2004)
"This book represents a highly important contribution to the field of combinatorial materials research…” (Angewandte Chemie International Edition, August 13, 2004)