Overview
From a to a is a short supplemental textbook that uses control of yeast mating type as a model for many aspects of cell determination in general. Topics covered include gene silencing; genetic recombination; differentiation; combinatorial gene regulation; mRNA transport to establish asymmetric cell division; signal transduction; evolution of genetic networks; and various aspects of cell biology, including action of cytoskeleton and bud site selection. The book includes a foreword by Mark Ptashne, author of A Genetic Switch.
Synopsis
From a to a is a short supplemental textbook that uses control of yeast mating type as a model for many aspects of cell determination in general. Topics covered include gene silencing; genetic recombination; differentiation; combinatorial gene regulation; mRNA transport to establish asymmetric cell division; signal transduction; evolution of genetic networks; and various aspects of cell biology, including action of cytoskeleton and bud site selection. The book includes a foreword by Mark Ptashne, author of A Genetic Switch.
Genetical Research
Overall, this is an excellent account of the mechanisms and concepts involved in the cellular differentiation that accompanies mating in yeast. It is very pleasurable to read and should appeal both to beginners and established yeast researchers. Furthermore, it could be beneficial for researchers working on other systems. As demonstrated very convincingly by Dr. Madhani, what we learn from yeast is likely to continue to offer some hints for our understanding of cellular differentiation in more complex systems.
Editorials
Genetical Research
Overall, this is an excellent account of the mechanisms and concepts involved in the cellular differentiation that accompanies mating in yeast. It is very pleasurable to read and should appeal both to beginners and established yeast researchers. Furthermore, it could be beneficial for researchers working on other systems. As demonstrated very convincingly by Dr. Madhani, what we learn from yeast is likely to continue to offer some hints for our understanding of cellular differentiation in more complex systems.Nature Cell Biology
Madhani's book thoughtfully highlights the elegant and ground-breaking work performed in yeast, and the resulting general mechanistic insights and molecular paradigms that emerged...In the specific sense that Madhani intended-as a manual for how yeast studies have led to general principles of eukaryotic cell differentiation-the book succeeds admirably, and proceeds in a logical, iterative and readable manner. It benefits from simple graphics and inserts in most chapters, which present specific concepts in the context of metazoans or of human disease...
...as an illustrative guide of how studies in a model organism can be illuminating for large areas of biology, Madhani's book is well worth the price.
Nature Genetics
"The lessons learned from yeast studies are stated refreshingly in a direct, matter-of-fact style, without repeating in detail the experiments that led to the knowledge. A description of the text of each concept is pictorially supported by a figure, and a full one-third of the space is allotted to figures-all features making it one of the most pleasantly readable books in biology...This book should be a 'must read' for anyone beginning to experiment with yeast. I suspect most experts in the yeast field are inundated with literature and selectively keep up with developments primarily in their immediate field. Reading this book will help such experts to appreciate developments in other areas of yeast research. Although yeast has only a handful of cell types, the principles learned form yeast studies are bound to help both beginners and seasoned researchers wishing to discover the underpinnings of cellular differentiation and development and the cause of disease in higher eukaryotes with vast arrays of cell types.