Fundamentals of Preparative and Nonlinear Chromatography

The second edition of Fundamentals of Preparative and Nonlinear Chromatography is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.

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Consolidates the fundamental concepts which form the basis for development of preparative separations by chromatography on the laboratory, pilot, and process scales. The volume presents the many issues that may be encountered while working in the field of preparative and process scale chromatography, and bridges the gap between the basic mathematics associated with the modeling of chromatographic separations and the phenomena observed during experimentation. Emphasis is on the illustration of equations and concepts to provide a physical image of the different chromatographic phenomena along with written narrative explanations. Considerable attention is also given to the application of these concepts to the optimization of the separation conditions. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Professor Guiochon has been a Distinguished Scientist at the University of Tennessee and Oak Ridge National Laboratory since 1987. Born and educated in France, he was a Professor of chemistry at Ecole Polytechnique and at the University of Paris until 1984 when he moved to the USA. He has been working on nolinear and preparative chromatography since 1984. He has been awarded the 1978 Silver Medal of C.N.R.S.; Honarary Doctorates by the Technical University of Budapest (Hungary) in 1991 and by the University of Pardubice (Czech Republic) in 1999; the 1991 Separation Sciences Award and the 1998 Chromatography Award of the American Chemical Society; and the EAS Award in Separation Sciences in 2001. In 1994 he received an Alexander von Humboldt Award as a Senior American Scientist.