Future of Hormone Therapy: What Basic and Clinical Studies Teach Us
James W. Simpkins (Editor), Meharvan Singh (Editor), New York Academy of Sciences StaffBooks.org participates in affiliate programs including Bookshop.org and the Amazon Services LLC Associates Program. We may earn a commission from qualifying purchases made through links on this page, at no additional cost to you.
Overview
This volume brings together contributions from basic scientists, epidemiologists, and practicing clinicians whose expertise or clinical practice involves the study or administration of gonadal hormones. Our current knowledge of the biology of gonadal hormones is assessed, and the question is explored of the gaps in knowledge that need to be addressed through additional research.
Other questions explored include the following: What is the appropriate population to study? What is the therapeutic window for hormone therapy and/or estrogen therapy? What are the appropriate formulations of HT and ET? What should be considered the most appropriate design for clinical trials that address the efficacy of HT/ET? What are appropriate surrogate markers of neurological decline/impairment? What are the best in vitro and in vivo models to address the efficacy of postmenopausal HT or ET?
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Synopsis
While preclinical and clinical evidence of the past supported the potential benefit of hormone replacement in women, the recently published Women's Health Initiative (WHI) suggests that hormone therapy does not protect against heart disease and dementia and may actually promote them. Selected papers from a November 2004 conference sponsored by the University of North Texas Health Science Center offer insight into the design and interpretation of the WHI studies, resulting in multiple explanations for the failure of the WHI to support the beneficial effects of hormone therapy. Annotation ©2005 Book News, Inc., Portland, OR