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Overview
Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.
The book contains black-and-white illustrations.
Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states. • Summarizes the latest findings in the fast moving field of peptide hormones and their regulatory mechanisms • Details how CCK and pancreatic secretion are regulated • Covers the core gut receptor and peptide families • Shows how PYY influences the exocrine pancreas and the newer peptide families, including amylin adrenomedullin • Discusses the regulation of gastric emptying and the actions of gut peptides on the endocrine pancreas • Reviews the role and regulation of insulin-like growth factors in normal and neoplastic GI cells • Explains the regulatory mechanisms of GI cancer growth by several GI hormones