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Gene Expression in Recombinant Microorganisms

Name: Gene Expression in Recombinant Microorganisms
Author: Alan Smith
ISBN: 9780824795436

by Alan Smith

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Overview

Describing the scientific and commercial applications of microbial recombinant DNA technology, this outstanding, single-source reference offers state-of-the-art reviews of gene expression in the most important classes of recombinant microorganisms -- providing numerous examples of the expression of homologous genes or heterologous gene products. Detailing various aspects of metabolic regulation and fermentation process technology, Gene Expression in Recombinant Microorganisms considers the basic biology and gene expression of Escherichia coli ... examines the gene expression system based on the indigenous 2-[mu]m plasmid of the yeast Saccharomyces cerevisiae ... elucidates the exploitation of the strongly inducible promoters associated with the growth of methylotrophic yeasts on methanol ... documents the fungal expression system based on the knowledge established for Aspergillus nidulans and Neurospora crassa ... analyzes gene expression and regulation in Streptomyces ... presents a unique collection of safety and regulatory considerations from around the world ... addresses specific measures to be taken for large-scale industrial operations ... speculates on future prospects and developments in biopharmaceutical research ... and much more. Thoroughly referenced, furnishing over 1400 literature citations, Gene Expression in Recombinant Microorganisms is an invaluable resource for biotechnologists, biochemists, applied and industrial microbiologists, molecular and cell biologists, virologists, bacteriologists, mycologists, microbial geneticists, bioprocess and chemical engineers, fermentation and regulatory affairs specialists, biosafety and research managers, and upper-level undergraduate and graduate students in these disciplines.

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Editorials

Applied Genetics News

...despite its extremely scientific orientation, is nevertheless written coherently and very lucidly.

Quarterly Review of Biology

...well written, well documented...a useful reference...valuable for peptide chemists as well as other interested biochemists and molecular biologists.

Booknews

Scientists with international reputations contribute up-to-date reviews on gene expression in recombinant organisms. Each chapter provides a specialist's account of gene expression in one of the important classes of microorganism used to express both homologous and heterologous genes. Each chapter describes the state-of-the-art for the expression system, provides examples of the expression of homologous and heterologous genes, documents the industrial and commercial exploitation of the system, and speculates on future prospects and developments. A chapter on regulatory and safety aspects reviews current legislation in the US, England, Europe, and elsewhere. The measures taken for large scale operation are also addressed. Annotation c. Book News, Inc., Portland, OR (booknews.com)