Overview
Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer".
The book contains black-and-white illustrations.
Editorials
From The Critics
Reviewer: David H. Barch, MD(VA Medical Center Chicago)Description: This volume presents the proceedings of a meeting of the recognized experts who spoke about the varied aspects of genetics and the environment on cancer development
Purpose: The purpose is to present the current understanding of the multifaceted interplay between genetic and environmental factors in the development of cancer.
Audience: Medical and graduate students, scientist in cancer research, and physicians interested in cancer biology are the audiences.
Features: Topics include molecular epidemiology, DNA repair, chromosomal damage, genetic susceptibility, population genetics, and the role of viruses in cancer. Many of the monographs contain extensive use of figures to explain complicated concepts and clarify data presentations. The presentations are state of the art and bring together a sampling of the broad spectrum of issues of the genetic and environmental factors involved in the development of cancer.
Assessment: This is not a textbook or comprehensive review, such as the IARC Monographs, and lacks the complete and well integrated overview of the field found in such a coordinated presentation. Some chapters include comprehensive reviews while others present only enough background to establish a framework for the topic discussed. In summary, these are state of the art presentations covering many of the diverse issues involved in the genetic and environmental influences on the development of cancer. The chapters provide interesting and educational entrances into many of the different issues in cancer risk, but the reader will frequently need other sources to complete a review of the topics.
David H. Barch
This volume presents the proceedings of a meeting of the recognized experts who spoke about the varied aspects of genetics and the environment on cancer development The purpose is to present the current understanding of the multifaceted interplay between genetic and environmental factors in the development of cancer. Medical and graduate students, scientist in cancer research, and physicians interested in cancer biology are the audiences. Topics include molecular epidemiology, DNA repair, chromosomal damage, genetic susceptibility, population genetics, and the role of viruses in cancer. Many of the monographs contain extensive use of figures to explain complicated concepts and clarify data presentations. The presentations are state of the art and bring together a sampling of the broad spectrum of issues of the genetic and environmental factors involved in the development of cancer. This is not a textbook or comprehensive review, such as the IARC Monographs, and lacks the complete and well integrated overview of the field found in such a coordinated presentation. Some chapters include comprehensive reviews while others present only enough background to establish a framework for the topic discussed. In summary, these are state of the art presentations covering many of the diverse issues involved in the genetic and environmental influences on the development of cancer. The chapters provide interesting and educational entrances into many of the different issues in cancer risk, but the reader will frequently need other sources to complete a review of the topics.3 Stars from Doody