Synopsis
Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
Nature Genetics
A compelling and deeply conceptual work about how biological reactions are regulated. . . . What this book provides is a guide to the concepts that form the framework for the gene expression field. The concepts allow students to understand the context of the facts and apply this information to their own studies. Students who are lucky enough to read Genes & Signals won't be slithering out of transcription seminars in 30 years, when our field has been condensed to an in silico version of an intermediary metabolism wall chart.