Genome

Told with the pacing of a great suspense novel, GENOME tells the very real story ofwhat could be the most ambitious scientific research project ever undertaken: the attempt to identify all the genes in the human body-estimated to number form 50,000 to 100,000. These genes located in the nucleus of the human cell, contain the blueprints for thousands of proteins that make up the body's tissues and vital organs, from muscles to the brain cells, as well as the instructions for making the thousands of chemicals that literally give us life. By mapping the human genome, scientists can study and even reproduce the chemical components that run the human machine. This knowledge will revolutionize the treatments for and the prevention of diseases. In this newly updated edition, the authors explain how we may soon have the ability to control our genetic fate. This unprecedented power, however, presents society with new dangers. In Genome, we learn much about the fascinating challenges-both scientific and ethical-that lie ahead.

Publishers Weekly

The nucleus of every cell in our bodies contains 50,000-100,000 genes. In an international ``gene mapping'' effort, scientists are attempting to determine the precise location of each gene on specific chromosomes. Although much of this research has been conducted in only the last 10 years, already the genes for Huntington's disease, muscular dystrophy and cystic fibrosis have been located, as well as ``susceptibility genes'' that predispose one to heart disease and, possibly, to alcoholism. Evidence links certain defective genes or the absence of other genes, to various cancers. The authors, both Wall Street Journal reporters, here offer an expert guided tour through the new world of genetic mapping, pausing to consider ethical dilemmas posed by genetic diagnosis of the unborn, privacy issues and potential use of individual genetic profiles by employers or insurance companies. First serial to Longevity and American Health. (Aug.)