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Overview
Handbook of Comparative Genomics: Principles and Methodology is a practical text for students and researchers covering basic and applied problems in the emerging field of comparative functional genomics. It offers a comparative perspective on the state of the art and key principles of genome sequencing, expression, evolution, and phylogenetics in organelles, prokaryotes, model organisms, and humans. Moreover, the Handbook provides a unique and thorough treatment of biological databases, analysis of the transcriptome and proteome, and the bioinformatic approaches for comparative genome analysis.The text begins with an introduction to important features of completely sequenced genomes from mitochondria, C. elegans and Arabidopsis to Drosophila and humans. The next section covers cutting-edge analytic approaches involving ESTs, SAGE, DNA microarrays, protein biochips, and 2D gel electrophoresis. The following section deals comprehensively with computational approaches to comparative genome and proteome sequence analysis, including sequence assembly, pattern searching, gene and protein function prediction, and structure prediction. The text concludes with a section discussing genome evolution and molecular phylogenetics. This timely and cutting-edge text also:
- Presents both the concepts and methodology of comparative genomics
- Reviews the basic principles of genomics and gene expression analysis
- Covers the bioinformatics approaches to comparative analysis
- Discusses analytic methods in proteomics and transcriptomics
- Includes a comprehensive list of Web resources
The authors draw upon their wealth of teaching and researchexperience to offer a coherent presentation appropriate for students, trainees, researchers, and scientists across the life sciences.
About the Author:
Cecilia Saccone is Professor of Molecular Biology at the University of Bari as well as the chair of the National Research Council (CNR) in Bari, Italy.
Graziano Pesole is a professor in the Department of Physiology and General Biochemistry at the University of Milan, Italy.AUTHCOMMENTS: This book provides an overview of the most relevant data derived from complete genome sequencing. Attained milestones and emerging discoveries are highlighted, while modern experimental methodologies and bioinformatic approaches are also described. The book wishes to become a guide for those who are approaching, with theoretical and practical aims, this intriguing new chapter of Biology. It has been divided into three sections: i) the state of the art in molecular knowledge of the main biological processes achieved with modern biotechnological tools and the recent insights genome sequencing have brought; ii) the most recent methodologies used in the field of Genomics, including high-throughput sequencing techniques, transcriptome and proteome analysis, as well as an extensive overview of the available bioinformatic tools; iii) topical issues in the field of Evolutionary Genomics and Molecular Phylogenetics.
Editorials
From the Publisher
"…an excellent addition to the field of comparative genomics." (ASM News, December 2004)“...will provide interesting reading and perspective to almost everyone involved in biological sciences.” (Quarterly Review of Biology, March 2004)
"...certainly deserves a place in institutional libraries...depth of material covered is right for the busy scientist...precise and detailed..." (Briefings in Functional Genomics & Proteomics, Vol 2(4), February 2004)
"...this book gives an illuminating look at the study of genomes through their sequence..." (Human Genomics, January 2004)
"...covers basic and applied problems in the emerging field of comparative functional genomics..." (Genetic Engineering News, Vol 23(14), 2003)