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Overview
High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell. High Content Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery discusses its use as a high throughput platform to understand the functions of genes, RNA, proteins, and other cellular constituents at the level of the living cell.
High Content Screening is assembled to assist both existing users of HCS, as well as investigators considering the addition of a discovery-driven platform to their research and development activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents, and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters.
Written by a team of world leaders in the field, High Content Screening is essential reading for senior scientists, advanced lab technicians, as well as students/post-docs who wish to apply HCS in their research and development programs.
Editorials
Reviewer: Scott J Weir, PharmD, PhD(University of Kansas Medical Center)
Description: This book describes the evolution and current state of high content screening (HCS).
Purpose: The purpose is to describe the history of HCS; the instrumentation, software applications and sample preparation involved in HCS; markers employed (they refer to reagents); bioinformatics practices and requirements; and examples of applications in cell biology and drug discovery. This book is applicable to current cell biology and drug discovery research. With the availability of siRNA libraries for commercial purchase by universities and industry, this book is very timely.
Audience: It is intended for researchers currently working in HCS or considering HCS as a research tool, whether in academia or industry. The authors, as a rule, are very credible. It is clear that care was taken to select authors who were, or are currently, very active in the field of HCS.
Features: The chapter by Dr Taylor on the history of HCS is very helpful. I particularly liked the sections addressing bioinformatics needs and the application examples. It would be wise, in my opinion, to plan on a second edition perhaps in three years, due to the rapidly changing HCS field.
Assessment: This is one of the better books I have reviewed. As someone who works in drug discovery and early drug development, I found the book very useful.