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Overview
Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
Synopsis
Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
Doody Review Services
Reviewer: Virginia Kaklamani, MD (Northwestern University )
Description: This book presents current evidence on the interaction between genes and hormones in the common malignancies of breast and prostate cancer. The role of estrogens and androgens as well as their receptors is put in the context of interpersonal variation due to genetic variation to describe the pathogenesis of these two malignancies.
Purpose: The purpose is to describe current evidence on the role of hormones in human malignancies. Since breast and prostate cancer are the two malignancies with a clear hormonal background, the authors focus on these. However, there is mention of other hormonally mediated malignancies such as testicular and endometrial cancer. Since treatment of these malignancies is primarily hormonally-based, the objectives of the authors are worthy. At the same time genetic factors are given consideration when they alter the metabolism or estrogens and androgens. This book covers the area of gene-hormone interaction meeting the authors' objectives.
Audience: This book is written for researchers who specialize in the field of hormone-gene interaction. The language is appropriate for an audience with prior background in that area. The authors are distinguished scientists with an impressive publication record in the field, making them credible authorities.
Features: The authors present evidence of the interaction between hormones and genes in human malignancies. The role of genetic variations leading to changes in hormonal metabolism is presented in a very unique way. The role of estrogen and androgen receptors in the pathogenesis of breast and prostate cancer is addressed. At the same time genes responsible for these two malignancies, such as BRCA1 and 2, are mentioned and the rationale behind endocrine treatment is given. Although the title of the book gives the impression that all malignancies will be discussed, breast and prostate cancer are discussed at length. A more appropriate title would be sex-hormones, genes and cancer.
Assessment: This book is of very high quality, offering the reader an updated reference in the field of sex-hormones, genes and cancer. The interaction between genes and hormones is discussed at length. Polymorphisms of genes responsible for estrogen and androgen metabolism are addressed as well as the use of hormonal agents in the treatment of breast and prostate cancer. This book is one of the tops in the field.
Editorials
From The Critics
Reviewer: Virginia Kaklamani, MD(Northwestern University )Description: This book presents current evidence on the interaction between genes and hormones in the common malignancies of breast and prostate cancer. The role of estrogens and androgens as well as their receptors is put in the context of interpersonal variation due to genetic variation to describe the pathogenesis of these two malignancies.
Purpose: The purpose is to describe current evidence on the role of hormones in human malignancies. Since breast and prostate cancer are the two malignancies with a clear hormonal background, the authors focus on these. However, there is mention of other hormonally mediated malignancies such as testicular and endometrial cancer. Since treatment of these malignancies is primarily hormonally-based, the objectives of the authors are worthy. At the same time genetic factors are given consideration when they alter the metabolism or estrogens and androgens. This book covers the area of gene-hormone interaction meeting the authors' objectives.
Audience: This book is written for researchers who specialize in the field of hormone-gene interaction. The language is appropriate for an audience with prior background in that area. The authors are distinguished scientists with an impressive publication record in the field, making them credible authorities.
Features: The authors present evidence of the interaction between hormones and genes in human malignancies. The role of genetic variations leading to changes in hormonal metabolism is presented in a very unique way. The role of estrogen and androgen receptors in the pathogenesis of breast and prostate cancer is addressed. At the same time genes responsible for these two malignancies, such as BRCA1 and 2, are mentioned and the rationale behind endocrine treatment is given. Although the title of the book gives the impression that all malignancies will be discussed, breast and prostate cancer are discussed at length. A more appropriate title would be sex-hormones, genes and cancer.
Assessment: This book is of very high quality, offering the reader an updated reference in the field of sex-hormones, genes and cancer. The interaction between genes and hormones is discussed at length. Polymorphisms of genes responsible for estrogen and androgen metabolism are addressed as well as the use of hormonal agents in the treatment of breast and prostate cancer. This book is one of the tops in the field.
3 Stars from Doody