HPLC Methods for Pharmaceutical Analysis: v. 1-4

Demetra D. Callas

This is a collection of procedures detailing multiple HPLC protocols for the top 200 drugs by number of prescriptions and the top 100 drugs by sales. The information is available on a CD-ROM that also incorporates a searchable database with numerous and extensive data fields. The purpose was to create a reference listing of HPLC analytical procedures for therapeutic drugs in biological fluids. There is currently no single source where such detailed and comprehensive information can be found. Laboratorians interested in developing HPLC methods for therapeutic drug monitoring (researchers and clinicians) will find this book very useful, saving them considerable time and effort. Each protocol is followed with pertinent and current references. By including all HPLC protocols for each drug, the authors provide an extensive bibliography. While this book is a large tome, it is well organized and easy to use because of the detailed table of contents in the beginning and the referencing indexes at the end of the volume. These include two cross-referencing indexes to the Merck Index and to Organic Chemistry of Drug Synthesis. Other indexes included are a name-monograph index, a molecular formula-drug name index, and a CAS registry number index. One of the best features of this volume is its availability in a CD-ROM format, which contains a searchable database with multiple fields of entry in addition to the indexes described, such as compound, retention time, matrix, author, column type, detector type, etc. This is a well organized volume that will save laboratorians a considerable amount of time and effort in searching for protocols and references to develop particular HPLC methods forpopular therapeutic drug monitoring. Furthermore, the CD-ROM allows for searches on fields such as retention time, matrix, detectors, etc., making this volume even more useful in laboratories with limited resources and particular requirements. Detailed yet condensed descriptions of procedures and extensive bibliographies give this book an encyclopedic appearance, complemented by the inclusion of cross-referencing indexes to other classic reference books. This is a much needed approach to cataloguing standard procedures for HPLC therapeutic drug monitoring methods. Users will certainly look forward to expanded and more extensive future editions where more therapeutic drugs will be covered.

Booknews

The very affordable print version of this database presents a collection of procedures for the analysis of 163 common pharmaceuticals using high-performance liquid chromatography HPLC. Techniques for each compound are grouped together, allowing researchers to combine features of different methods. In addition, drug assay methods are provided for drugs in biological fluids, such as blood and urine, as well as for bulk and formulated drugs. Indexes by name, molecular formula, and CAS Registry Number, and cross references to "The Merck Index" and "The Organic Chemistry of Drug Synthesis" complete the work. Annotation c. by Book News, Inc., Portland, Or.

From The Critics

Reviewer: Demetra D. Callas, PhD(Loyola University Medical Center)
Description: This is a collection of procedures detailing multiple HPLC protocols for the top 200 drugs by number of prescriptions and the top 100 drugs by sales. The information is available on a CD-ROM that also incorporates a searchable database with numerous and extensive data fields.
Purpose: The purpose was to create a reference listing of HPLC analytical procedures for therapeutic drugs in biological fluids. There is currently no single source where such detailed and comprehensive information can be found.
Audience: Laboratorians interested in developing HPLC methods for therapeutic drug monitoring (researchers and clinicians) will find this book very useful, saving them considerable time and effort.
Features: Each protocol is followed with pertinent and current references. By including all HPLC protocols for each drug, the authors provide an extensive bibliography. While this book is a large tome, it is well organized and easy to use because of the detailed table of contents in the beginning and the referencing indexes at the end of the volume. These include two cross-referencing indexes to the Merck Index and to Organic Chemistry of Drug Synthesis. Other indexes included are a name-monograph index, a molecular formula-drug name index, and a CAS registry number index. One of the best features of this volume is its availability in a CD-ROM format, which contains a searchable database with multiple fields of entry in addition to the indexes described, such as compound, retention time, matrix, author, column type, detector type, etc.
Assessment: This is a well organized volume that will save laboratorians a considerable amount of time and effort in searching for protocols and references to develop particular HPLC methods for popular therapeutic drug monitoring. Furthermore, the CD-ROM allows for searches on fields such as retention time, matrix, detectors, etc., making this volume even more useful in laboratories with limited resources and particular requirements. Detailed yet condensed descriptions of procedures and extensive bibliographies give this book an encyclopedic appearance, complemented by the inclusion of cross-referencing indexes to other classic reference books. This is a much needed approach to cataloguing standard procedures for HPLC therapeutic drug monitoring methods. Users will certainly look forward to expanded and more extensive future editions where more therapeutic drugs will be covered.

4 Stars! from Doody