Immunogenetics: Advances and Education, Vol. 35
J.A. Madrigal (Editor), Alejandro Madrigal, Derek Middleton (Editor), Margita BencovBooks.org participates in affiliate programs including Bookshop.org and the Amazon Services LLC Associates Program. We may earn a commission from qualifying purchases made through links on this page, at no additional cost to you.
Overview
The objective underlying this book is educational, aiming to advance the development of immunogenetics/hisompatibility and to encourage the international collaboration that is so necessary for the international transplant programme and for research into the genetic predisposition to develop diseases associated with genes in the HLA complex. The revolution in high-tech molecular biological genome technology has given rise to a prodigious development of molecular techniques for the polymorphism analysis of HLA and the subsequent application of research results in clinical practice. Many new alleles have been discovered and different mechanisms have been shown to generate these new alleles. This has improved both diagnostic efficiency and increased the success of transplantation. Topics covered include HLA associated susceptibility to autoimmune disease. Strategies and efficiency of BMDW and benefit of collaboration. Optimum selection of unrelated bone marrow donor and extension of the pool of suitable donors by determination of possible mismatches. Identification of sibling pairs using microsatellites across the HLA region. HLA in kidney transplantation. Eurotransplant facts and figures. HLA typing from serology to molecular biology. Evolution of DNA based typing in HLA laboratories. HLA and paternity testing.
The book contains black-and-white illustrations.
Synopsis
The objective underlying this book is educational, aiming to advance the development of immunogenetics/histocompatibility and to encourage the international collaboration that is so necessary for the international transplant programme and for research into the genetic predisposition to develop diseases associated with genes in the HLA complex.
The revolution in high-tech molecular biological genome technology has given rise to a prodigious development of molecular techniques for the polymorphism analysis of HLA and the subsequent application of research results in clinical practice. Many new alleles have been discovered and different mechanisms have been shown to generate these new alleles. This has improved both diagnostic efficiency and increased the success of transplantation.
Topics covered include HLA associated susceptibility to autoimmune disease. Strategies and efficiency of BMDW and benefit of collaboration. Optimum selection of unrelated bone marrow donor and extension of the pool of suitable donors by determination of possible mismatches. Identification of sibling pairs using microsatellites across the HLA region. HLA in kidney transplantation. Eurotransplant facts and figures. HLA typing from serology to molecular biology. Evolution of DNA based typing in HLA laboratories. HLA and paternity testing.
Ruta M. Radvany
This is a report of the proceedings of the NATO Advanced Research Workshop held during the First Congress of the Slovak Foundation in Immunogenetics. The book is a new volume in the NATO series of publications and contains chapters by selected, well recognized experts in immunogenetics/histocompatibility. The stated aim of the workshop was to advance the development of immunogenetics/histocompatibility in Slovakia and other countries of NATO. The book has met the editors' objective in that it provides an up to-date review of selected technical, practical, and theoretical issues in histocompatibility and its application to medicine. This book is most appropriate for transplant physicians, laboratorians, and specialists in autoimmune disease and bone marrow transplantation. Students and residents will find some chapters informative, but substantial background knowledge in histocompatibility is needed to fully appreciate the contents. Immunogeneticists will appreciate the in-depth discussion of some more recent findings. The book is attractive. The text contains clear tables and graphs. Some chapters have illustrations. All of these are adequately described and easily found. References are appropriate and adequate in number. The book is unique in that it presents the practical aspect of histocompatibility from the European perspective. Similarly, the preface containing history of Slovakia should be of interest to those working in the area of heredity and human disease. It is divided in seven sections: laboratory accreditation; HLA diversity; HLA and disease; bone marrow transplantation; HLA and non HLA aspects in transplantation; solid organ and cornea transplantation; and HLAtyping. This is a good book for a medical, research, or clinical laboratory library, and as personal reference material for immunogeneticists, directors of histocompatibility laboratories, and transplant physicians.
Editorials
From The Critics
Reviewer: Ruta M. Radvany, PhD(Loyola University Medical Center)Description: This is a report of the proceedings of the NATO Advanced Research Workshop held during the First Congress of the Slovak Foundation in Immunogenetics. The book is a new volume in the NATO series of publications and contains chapters by selected, well recognized experts in immunogenetics/histocompatibility.
Purpose: The stated aim of the workshop was to advance the development of immunogenetics/histocompatibility in Slovakia and other countries of NATO. The book has met the editors' objective in that it provides an up to-date review of selected technical, practical, and theoretical issues in histocompatibility and its application to medicine.
Audience: This book is most appropriate for transplant physicians, laboratorians, and specialists in autoimmune disease and bone marrow transplantation. Students and residents will find some chapters informative, but substantial background knowledge in histocompatibility is needed to fully appreciate the contents. Immunogeneticists will appreciate the in-depth discussion of some more recent findings.
Features: The book is attractive. The text contains clear tables and graphs. Some chapters have illustrations. All of these are adequately described and easily found. References are appropriate and adequate in number. The book is unique in that it presents the practical aspect of histocompatibility from the European perspective. Similarly, the preface containing history of Slovakia should be of interest to those working in the area of heredity and human disease.
Assessment: It is divided in seven sections: laboratory accreditation; HLA diversity; HLA and disease; bone marrow transplantation; HLA and non HLA aspects in transplantation; solid organ and cornea transplantation; and HLA typing. This is a good book for a medical, research, or clinical laboratory library, and as personal reference material for immunogeneticists, directors of histocompatibility laboratories, and transplant physicians.
From The Critics
Reviewer: Ruta M. Radvany, PhD(Loyola University Medical Center)Description: This is a report of the proceedings of the NATO Advanced Research Workshop held during the First Congress of the Slovak Foundation in Immunogenetics. The book is a new volume in the NATO series of publications and contains chapters by selected, well recognized experts in immunogenetics/histocompatibility.
Purpose: The stated aim of the workshop was to advance the development of immunogenetics/histocompatibility in Slovakia and other countries of NATO. The book has met the editors' objective in that it provides an up to-date review of selected technical, practical, and theoretical issues in histocompatibility and its application to medicine.
Audience: This book is most appropriate for transplant physicians, laboratorians, and specialists in autoimmune disease and bone marrow transplantation. Students and residents will find some chapters informative, but substantial background knowledge in histocompatibility is needed to fully appreciate the contents. Immunogeneticists will appreciate the in-depth discussion of some more recent findings.
Features: The book is attractive. The text contains clear tables and graphs. Some chapters have illustrations. All of these are adequately described and easily found. References are appropriate and adequate in number. The book is unique in that it presents the practical aspect of histocompatibility from the European perspective. Similarly, the preface containing history of Slovakia should be of interest to those working in the area of heredity and human disease.
Assessment: It is divided in seven sections: laboratory accreditation; HLA diversity; HLA and disease; bone marrow transplantation; HLA and non HLA aspects in transplantation; solid organ and cornea transplantation; and HLA typing. This is a good book for a medical, research, or clinical laboratory library, and as personal reference material for immunogeneticists, directors of histocompatibility laboratories, and transplant physicians.
Ruta M. Radvany
This is a report of the proceedings of the NATO Advanced Research Workshop held during the First Congress of the Slovak Foundation in Immunogenetics. The book is a new volume in the NATO series of publications and contains chapters by selected, well recognized experts in immunogenetics/histocompatibility. The stated aim of the workshop was to advance the development of immunogenetics/histocompatibility in Slovakia and other countries of NATO. The book has met the editors' objective in that it provides an up to-date review of selected technical, practical, and theoretical issues in histocompatibility and its application to medicine. This book is most appropriate for transplant physicians, laboratorians, and specialists in autoimmune disease and bone marrow transplantation. Students and residents will find some chapters informative, but substantial background knowledge in histocompatibility is needed to fully appreciate the contents. Immunogeneticists will appreciate the in-depth discussion of some more recent findings. The book is attractive. The text contains clear tables and graphs. Some chapters have illustrations. All of these are adequately described and easily found. References are appropriate and adequate in number. The book is unique in that it presents the practical aspect of histocompatibility from the European perspective. Similarly, the preface containing history of Slovakia should be of interest to those working in the area of heredity and human disease. It is divided in seven sections: laboratory accreditation; HLA diversity; HLA and disease; bone marrow transplantation; HLA and non HLA aspects in transplantation; solid organ and cornea transplantation; and HLAtyping. This is a good book for a medical, research, or clinical laboratory library, and as personal reference material for immunogeneticists, directors of histocompatibility laboratories, and transplant physicians.Booknews
Comprises the proceedings of the NATO Advanced Research Workshop on the First Congress of Slovak Foundation Education in Immunogenetics held in September 1996 in Bratislava, Slovakia. The 30-some contributions are divided into seven sections: accreditation with European and American histocompatibility immunogenetics organizations; HLA diversity and applications; HLA and diseases; bone marrow transplantation; transplantation, HLA, and non-HLA aspects; solid organ and eye cornea transplantation; and HLA users. The proceedings are introduced with a brief synopsis of Slovakian history describing the glorious Moravian empire from the 5th century onward in charmingly stilted English. A few contributions are written in similarly stilted English, or are studded with typos, although they are by no means impossible to decipher. Annotation c. by Book News, Inc., Portland, Or.4 Stars! from Doody