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Synopsis
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.
David A. Ehrmann
This volume in the Contemporary Endocrinology Series is a multiauthored text designed to summarize the current understanding of the importance of insulin resistance, particularly as it relates to non-diabetic states. The purpose is to provide the reader with information about the importance of insulin resistance in non-diabetic states. It is appropriate for any clinician or investigator who encounters adult patients. The spectrum of metabolic disturbances associated with insulin resistance is broad, making this book appealing to generalists as well as subspecialists. This book is structured in three parts. Part one covers genetic and environmental factors affecting insulin action; part two covers the pathophysiology of insulin resistance; and part three deals with clinical syndromes associated with insulin resistance. This book is particularly useful in that it bridges the gaps in what is known about the fundamental elements of insulin action and the clinical sequelae. For example, the complexities of the relationship between obesity and insulin resistance are clearly handled. This is an excellent and welcome addition to the field: concise, clearly written, and current.