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Synopsis
Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Doody Review Services
Reviewer:Celso Agner, MD, MSc(University of Illinois at Chicago College of Medicine)
Description:The potential membrane effects on behavior have been proven in the past. This book addresses the membrane as the controller of cellular signaling.
Purpose:The purpose is to determine the nature of the lipid rafts in the determination of cell signaling.
Audience:Neuroscientists are the main targets for this book.
Features:The 10 chapters are written by 25 authors. The thrust of the book is to address the function of lipids in the transmission of signals from the extracellular environment to the internal cellular milieu. The incorporation of cholesterol particles in the membranes determines reproduction of genetic behaviors not previously imagined. There is also a direct relationship with specific membrane diseases that will potentially be managed by targeted therapy to the cellular membrane lipids.
Assessment:This is a good acquisition for general medical and neuroscience libraries.