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Overview
"Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine." Metal Complex-DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.Synopsis
The importance of metal-DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.
This book provides an overview of metal-DNA interactions, the mechanism of their interaction, metal-based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal-based drugs.
Editorials
From the Publisher
"An impressive overview of the great diversity of current research." (Angewandte Chemie International Edition, February 2010)"An essential part of the library for laboratories involved in bioinorganic and medicinal inorganic chemistry." (Chemistry World, September 2009)