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Overview
Assessment and management of predisposition to specific diseases is currently a very hot dimension of medicine. Once purely the realm of epidemiologists, the emergence of molecular genetic testing and other highly sophisticated diagnostic and prognostic techniques has made risk assessment and care a part of the work of many clinicians—from GPs to the super-specialist. Nowhere has the study of "prognostic factors" been more high-profile (and more clinically fruitful) than in breast cancer. Breakthroughs in the identification of genes associated with breast carcinoma, particularly BRCA1 and 2, as well as other risk factors, influence not only how patients are screened, but also how they are treated. With one in nine women likely to contract breast cancer in her lifetime, the significance of identifying and managing the high-risk patient is evident.
The book contains black-and-white illustrations.
This is a unique reference with coverage of the epidemiology, genetics, and clinical management of women at high risk for breast cancer. The assessment and management of predisposition to the disease is addressed, incorporating prognostic factors, patient screening, genetic testing, and other topics critical to the work of physicians treating those with breast disease. This is the only text with a synthesis of the vast scientific and clinical data on the patient at increased risk. Contributions from prominent experts in the field are included. This book is a summary of the most recent advances in genetics, epidemiology, the role of mammography, pharmacologic and surgical prevention and treatment, and legal/ethical considerations.
Synopsis
Assessment and management of predisposition to specific diseases is currently a very hot dimension of medicine. Once purely the realm of epidemiologists, the emergence of molecular genetic testing and other highly sophisticated diagnostic and prognostic techniques has made risk assessment and care a part of the work of many clinicians—from GPs to the super-specialist. Nowhere has the study of "prognostic factors" been more high-profile (and more clinically fruitful) than in breast cancer. Breakthroughs in the identification of genes associated with breast carcinoma, particularly BRCA1 and 2, as well as other risk factors, influence not only how patients are screened, but also how they are treated. With one in nine women likely to contract breast cancer in her lifetime, the significance of identifying and managing the high-risk patient is evident.
Booknews
Representing nearly every discipline that applies, contributors explain to clinicians the foundations of risk management and its application to reducing the risk of breast cancer, providing specific tools for attending to the health-care needs of adult women that can be incorporated into daily clinical practice. Among the aspects they examine are clinical characteristics of genetically determined breast cancer, contemporary breast imaging in the high-risk patient, developing a risk assessment clinic, chemoprevention to reduce risk, psychological management, and legal and ethical issues. Annotation c. Book News, Inc., Portland, OR (booknews.com)