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Overview
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Synopsis
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Doody Review Services
Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description:This book contains a series of reviews on immunostimulatory DNA. Aspects of receptor recognition, signaling pathways, utility in vaccine development, and several direct applications are discussed.
Purpose:The goal is to provide a broad overview of the properties and applications of specific DNA sequences known to stimulate host immune responses. This is a worthwhile endeavor and the book is of value.
Audience:The target audience includes a broad range of scientists working on immune mechanisms, vaccine development, and related areas. The material will be of interest to graduate students, research fellows, and senior investigators. The chapters are authored by reputable and experienced scientists.
Features:The current interest in vaccine development makes this a timely contribution. Since the routine adjuvants usually employed in animal studies are not suitable for use in man, new strategies to enhance host immune response are constantly sought. The inmethylated CpG repeats common in bacterial DNA have been known for some years to exert a stimulatory effect on immune responses. This book reviews these effects in a set of 31 chapters. Following two introductory, largely historical chapters, aspects of receptor recognition, signaling pathways, and cellular effects are reviewed. These sections are followed by discussions of various vaccination strategies including application to cancer, allergy and autoimmune disease. Each chapter has a suitable bibliography thus providing a broad set of references. Investigators interested in the overall utility of these DNA sequences will find useful material. As with many similar books, a chapter highlighting limitations and caveats would have been valuable.
Assessment:This is a valuable addition to the vaccinology library. Interest in this area is high and the book is timely.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This book contains a series of reviews on immunostimulatory DNA. Aspects of receptor recognition, signaling pathways, utility in vaccine development, and several direct applications are discussed.
Purpose: The goal is to provide a broad overview of the properties and applications of specific DNA sequences known to stimulate host immune responses. This is a worthwhile endeavor and the book is of value.
Audience: The target audience includes a broad range of scientists working on immune mechanisms, vaccine development, and related areas. The material will be of interest to graduate students, research fellows, and senior investigators. The chapters are authored by reputable and experienced scientists.
Features: The current interest in vaccine development makes this a timely contribution. Since the routine adjuvants usually employed in animal studies are not suitable for use in man, new strategies to enhance host immune response are constantly sought. The inmethylated CpG repeats common in bacterial DNA have been known for some years to exert a stimulatory effect on immune responses. This book reviews these effects in a set of 31 chapters. Following two introductory, largely historical chapters, aspects of receptor recognition, signaling pathways, and cellular effects are reviewed. These sections are followed by discussions of various vaccination strategies including application to cancer, allergy and autoimmune disease. Each chapter has a suitable bibliography thus providing a broad set of references. Investigators interested in the overall utility of these DNA sequences will find useful material. As with many similar books, a chapter highlighting limitations and caveats would have been valuable.
Assessment: This is a valuable addition to the vaccinology library. Interest in this area is high and the book is timely.
From The Critics
Researchers in microbiology, pathology, allergy and immunology, and biomedical science review the activation of the mammalian immune system by bacterial DNA and consider the application of immunostimulatory DNA sequences (ISS) in clinical medicine. They survey the latest findings on the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious diseases, allergy, cancer, and inflammation and autoimmunity. The book is of interest to immunologists, bacteriologists, pharmacists, allergists, and infectious disease specialists. Raz is affiliated with the University of California-San Diego. Annotation c. Book News, Inc., Portland, OR3 Stars from Doody