Molecular Genetics and Immunoanalysis in Blood Coagulation

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On blood coagulation proteins and their role in hemostasis. Discusses the molecular abnormalities in patients with disorders of hemostasis and, relative thereto, the use of immunochemical analysis and recombinant DNA techniques. Current findings with regard to the molecular biology of factor VIII deficiency (hemophilia A), factor IX deficiency (hemophilia B) and von Willebrand's disease are emphasized. Assesses carrier status and characterizes molecular abnormalities in the fetus and in typical "variant" disorder types and reflects the considerable advances made in the last few years in the understanding of the molecular basis for both hereditary and acquired hemorrhage disorders. Acidic paper. Annotation c. Book News, Inc., Portland, OR (booknews.com)