Overview
The most comprehensive reference on neuromuscular diseases and disorders!
A Doody's Core Title
5 STAR DOODY'S REVIEW!
"This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology....Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders."—Doody's Review Service
Edited by the world’s leading authority, this is the reference of choice for neurologists who a need a complete, authoritative work on muscle diseases and disorders. Features over 100 color illustrations of clinical, pathological, and imaging studies in myology. Includes important information on muscular dystrophy and inflammatory disease as well as a better understanding of mitochondrial diseases and the genetic basis of inherited diseases.
"...important advances in the cellular and molecular understanding of muscular disorders have precipitated the wealth of new information presented here on such sujbects as muscular dystrophy, inflammation, mitochondrial disease,etc.
Synopsis
For the third edition of this major reference work, all chapters were revised or written anew, and eight new chapters were added: on extraocular muscles, immune mechanisms in muscle diseases, Bethlem myopathy, x-linked vacuolar myopathies, myofibrillar myopathies, cardio-myopathies associated with muscular dystrophies, generalized peripheral nerve hyper-excitability, and hereditary inclusion body myopathies. An international group of 97 specialists contributed 70 chapters, which are grouped into three major parts: scientific basis, general approaches to neuromuscular diseases, and diseases of muscle. Among the 36 chapters on diseases are 12 on muscular dystrophies. Other topics include parasitic myositis, disorders of lipid metabolism, myoglobinura, lysosomal metabolism and its relevance to skeletal muscle, neuromuscular transmission, the extracellular matrix, and molecular physiology of the cross-bridge cycle. Engel is at the Mayo Clinic College of Medicine in Rochester, Minn.; Franzini-Armstrong is in the department of cell and developmental biology at the U. of Pennsylvania School of Medicine. Annotation © 2004 Book News, Inc., Portland, OR
Doody Review Services
Reviewer:Charlene Hafer-Macko, MD(University of Maryland School of Medicine)
Description:Myology has long been considered to be the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a substantial update from the second edition in 1994 and reflects the clinical, pathologic, and molecular biology advances over the past decade. The majority of chapters were revised, entirely rewritten, or are new additions reflecting the molecular biology advances in our understanding of muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle protein.
Purpose:The new edition of Myology fulfilled the editors' objective to provide a comprehensive review of muscle biology and skeletal muscle disease.
Audience:The editors brought together a group of 97 distinguished international authors to contribute and compile this latest edition of Myology. Specific topics are comprehensive with complete and contemporary references cited. This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology. Specific chapters would be of interest to scientists and clinicians in rheumatology, ophthalmology, and genetics.
Features:This edition is still organized in three parts: scientific basis, general approaches to neuromuscular diseases, and diseases of muscle. Part one was significantly expanded and reorganized based on the extraordinary amount of new molecular biology research defining regulatory pathways, signaling cascades, and cellular mechanisms controlling muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle proteins. New research on the molecular and functional aspects of plasmalemma ion channels and pumps are presented. Scientific advances on muscle activation and control of muscle activity are reviewed. New color plates vividly illustrate how protein configuration and protein-protein interactions control muscle contraction as well as ion channel and pump function. The Diseases of Muscle Section was updated throughout. For example, Limb-Girdle Muscular Dystrophies (LGMD) in 1994 included one dominant and three recessive forms. Now, the 2004 edition presents six dominant and ten recessive forms. This revised chapter benefits from advances in genetics that characterized families within LGMD to refine our definition of the clinical and pathologic differences and similarities of these distinct disorders that all classified as LGMD. Tables in this chapter clarify the large number of abnormal gene defects with their proteins and phenotypic classifications for these muscular dystrophies. Another table outlines specific abnormal proteins associated with LGMD, their phenotypes, and special diagnostic considerations based on specific protein expression. Conceptual models show the complex cellular processes involved in LGMD, including extracellular matrix, plasma membrane and associated proteins, sarcomeric proteins, nuclear envelope, and enzymes that can all result in LGMD. This chapter highlights the normal function of each of these proteins associated with LGMD and outlines physiologic experiments and mutation studies to demonstrate how genetic and protein abnormalities give rise to the specific phenotypic disease manifestations. Finally, this chapter presents clinical presentation of each LGMD, their clinical evaluation and muscle biopsy, protein, and genetic studies. The illustrations in the Diseases of Muscle section complement the text to exemplify specific clinical characteristics, expected electrophysiologic and ancillary diagnostic results, and characteristic findings on muscle biopsy to aid the practitioner in diagnosis.
Assessment:Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a timely substantial update to the second edition in 1994 and reflects the advances in clinical, pathologic, and molecular biology over the past decade.
Editorials
From The Critics
Reviewer: Charlene Hafer-Macko, MD(University of Maryland School of Medicine)Description: Myology has long been considered to be the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a substantial update from the second edition in 1994 and reflects the clinical, pathologic, and molecular biology advances over the past decade. The majority of chapters were revised, entirely rewritten, or are new additions reflecting the molecular biology advances in our understanding of muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle protein.
Purpose: The new edition of Myology fulfilled the editors' objective to provide a comprehensive review of muscle biology and skeletal muscle disease.
Audience: The editors brought together a group of 97 distinguished international authors to contribute and compile this latest edition of Myology. Specific topics are comprehensive with complete and contemporary references cited. This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology. Specific chapters would be of interest to scientists and clinicians in rheumatology, ophthalmology, and genetics.
Features: "This edition is still organized in three parts: scientific basis, general approaches to neuromuscular diseases, and diseases of muscle. Part one was significantly expanded and reorganized based on the extraordinary amount of new molecular biology research defining regulatory pathways, signaling cascades, and cellular mechanisms controlling muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle proteins. New research on the molecular and functional aspects of plasmalemma ion channels and pumps are presented. Scientific advances on muscle activation and control of muscle activity are reviewed. New color plates vividly illustrate how protein configuration and protein-protein interactions control muscle contraction as well as ion channel and pump function. The Diseases of Muscle Section was updated throughout. For example, Limb-Girdle Muscular Dystrophies (LGMD) in 1994 included one dominant and three recessive forms. Now, the 2004 edition presents six dominant and ten recessive forms. This revised chapter benefits from advances in genetics that characterized families within LGMD to refine our definition of the clinical and pathologic differences and similarities of these distinct disorders that all classified as LGMD. Tables in this chapter clarify the large number of abnormal gene defects with their proteins and phenotypic classifications for these muscular dystrophies. Another table outlines specific abnormal proteins associated with LGMD, their phenotypes, and special diagnostic considerations based on specific protein expression. Conceptual models show the complex cellular processes involved in LGMD, including extracellular matrix, plasma membrane and associated proteins, sarcomeric proteins, nuclear envelope, and enzymes that can all result in LGMD. This chapter highlights the normal function of each of these proteins associated with LGMD and outlines physiologic experiments and mutation studies to demonstrate how genetic and protein abnormalities give rise to the specific phenotypic disease manifestations. Finally, this chapter presents clinical presentation of each LGMD, their clinical evaluation and muscle biopsy, protein, and genetic studies. The illustrations in the Diseases of Muscle section complement the text to exemplify specific clinical characteristics, expected electrophysiologic and ancillary diagnostic results, and characteristic findings on muscle biopsy to aid the practitioner in diagnosis. "
Assessment: Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a timely substantial update to the second edition in 1994 and reflects the advances in clinical, pathologic, and molecular biology over the past decade.
5 Stars! from Doody