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Overview
Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.
The book contains black-and-white illustrations.
It is recognized that steroids, which are synthesized from cholesterol in endocrine glands, influence the development and function of the brain. This book unveils new physiological properties of neurosteroids, the related steroids that can form and metabolize in the brain, as well as throughout the entire nervous system. It addresses the involvement of neurosteroids in the function of the GABA-receptor and other neurotransmitter receptors such as nicotinic, NMDA, and sigma receptors. It reveals the trophic effects on neurons in culture, glial cells both in vitro and in vivo, Schwann cells, and oligodendrocytes. These current and innovative discussions may be the key to discovering new approaches to the repair of the nervous system after trauma and/or neurodegenerative diseases.
Synopsis
Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.Editorials
Hassan Ahmed Al-Shatoury
In this book, neurosteroids are clearly distinguished from other types of steroids. A large number of studies that focus on biosynthesis, metabolism, and different effects of neurosteroids on the nervous system are discussed. There is also an explanation of how these agents can be of significant therapeutic value in many neurological disorders. The purpose is to make the reader understand the physiochemical properties of neurosteroids to see how they may be used as pharmacological agents. The objectives fulfilled in this book are worthy and meet those of the editors. According to the editors, this book is written for neurobiologists, endocrinologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians. In addition, this book will probably also be of interest to practicing neurologists. The editors of have been involved with research on the subject for a long time and are among the pioneers in this field. The topics covered include the definition of neurosteroids and their biosynthesis and regulation. This is followed by a discussion of the different effects of these neurosteroids on the nervous system. The future and possible use of these compounds as pharmacological agents in clinical practice are also discussed. In addition, the authors talk about the different actions of neurosteroids on the nervous system receptors. The chapters on their effects on the GABAergic receptors are especially well written. This is one of the first books devoted entirely to neurosteroids, and many studies done in this field over the past 15 years are summarized. This is a unique text in the field of neurosteroids. It is based on research spanning many years and places the reader onthe first step of studying these pharmacological agents that may be of important therapeutic value especially in neurotrophicity, behavior, and age-related cerebral dysfunction. This is a rediscovery of an exciting field of research for all neuroscientists.Booknews
Not really new, but recently discovered by Baulieu biochemistry and human reproduction, College of France, Paris himself. Scientists and clinical researchers join him in reviewing all facets of neurosteroids known to be involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. Pointing the way to new pharmaceutical agents that may be of significant therapeutic value in aging mental functions and other problems, they look at the role of neurosteroids in brain development and plasticity, and their neuromodulary influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Annotation c. Book News, Inc., Portland, OR booknews.comFrom The Critics
Reviewer: Hassan Ahmed Al-Shatoury, MD(University of Illinois at Chicago College of Medicine)Description: In this book, neurosteroids are clearly distinguished from other types of steroids. A large number of studies that focus on biosynthesis, metabolism, and different effects of neurosteroids on the nervous system are discussed. There is also an explanation of how these agents can be of significant therapeutic value in many neurological disorders.
Purpose: The purpose is to make the reader understand the physiochemical properties of neurosteroids to see how they may be used as pharmacological agents. The objectives fulfilled in this book are worthy and meet those of the editors.
Audience: According to the editors, this book is written for neurobiologists, endocrinologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians. In addition, this book will probably also be of interest to practicing neurologists. The editors of have been involved with research on the subject for a long time and are among the pioneers in this field.
Features: The topics covered include the definition of neurosteroids and their biosynthesis and regulation. This is followed by a discussion of the different effects of these neurosteroids on the nervous system. The future and possible use of these compounds as pharmacological agents in clinical practice are also discussed. In addition, the authors talk about the different actions of neurosteroids on the nervous system receptors. The chapters on their effects on the GABAergic receptors are especially well written. This is one of the first books devoted entirely to neurosteroids, and many studies done in this field over the past 15 years are summarized.
Assessment: This is a unique text in the field of neurosteroids. It is based on research spanning many years and places the reader on the first step of studying these pharmacological agents that may be of important therapeutic value especially in neurotrophicity, behavior, and age-related cerebral dysfunction. This is a rediscovery of an exciting field of research for all neuroscientists.
4 Stars! from Doody