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Overview
In Neurotherapeutics: Emerging Strategies neuroscientists, clinicians, and industry-based pharmacologists and chemists review emerging approaches for the treatment of diseases of the central nervous system. The contributors-all key investigators of novel therapeutics-focus on developing rational strategies for drug design based on the new understanding of the underlying pathophysiology of central nervous system diseases. In the process, the contributors review the efficacy and mechanisms of current treatments as well as the latest research results and their potential therapeutic impact. Common to all chapters is the promise held out by newly cloned receptor subtypes of therapeutics with improved selectivity and potency. Also explored is the potential for novel therapeutics from a developing understanding of signal transduction. The diseases discussed range from affective disorders and Alzheimer's disease to Parkinson's disease and schizophrenia, as well as anxiety, panic disorders, stroke, epilepsy, and Huntington's disease.
The book contains black-and-white illustrations.
Synopsis
In Neurotherapeutics: Emerging Strategies neuroscientists, clinicians, and industry-based pharmacologists and chemists review emerging approaches for the treatment of diseases of the central nervous system. The contributors-all key investigators of novel therapeutics-focus on developing rational strategies for drug design based on the new understanding of the underlying pathophysiology of central nervous system diseases. In the process, the contributors review the efficacy and mechanisms of current treatments as well as the latest research results and their potential therapeutic impact. Common to all chapters is the promise held out by newly cloned receptor subtypes of therapeutics with improved selectivity and potency. Also explored is the potential for novel therapeutics from a developing understanding of signal transduction. The diseases discussed range from affective disorders and Alzheimer's disease to Parkinson's disease and schizophrenia, as well as anxiety, panic disorders, stroke, epilepsy, and Huntington's disease.
Gabriel Gonzalez-Portillo
In this volume of Contemporary Neuroscience, the authors (neuroscientists, industry-based pharmacologists, chemists, and clinicians) review the latest advances in the treatment of several neurological and psychiatric diseases. The purpose is to describe new advances in pharmacological treatment of diseases that are under intensive research. The authors achieve their objectives. The book is directed at neuroscientists, neurologists, psychiatrists, neurosurgeons, and pharmacologists. The first three chapters are devoted to psychiatric diseases. In the first chapter there is a brief description of the etiology of schizophrenia, followed by an extensive review of the different sites of action (receptor subtypes) of antipsychotic drugs. The next chapter describes the transmembrane cellular signal transduction in affective disorders and, in the third chapter, the different mechanisms of action of drugs for anxiety and panic disorders are explained. In the next two chapters, the neurological manifestations of acute and chronic diseases and opioids and mechanism of pain are reviewed. In the former, the food intake suppression induced by immunomodulators is described as well as the potential pharmacological interventions; in the latter, the existence of multiple opioid receptors and the role of N-methyl-D-aspartate (NNMA) and nitric oxide systems in opioid tolerance are discussed. The remaining chapters are dedicated to specific neurological diseases that are under intensive research: epilepsy, neuroprotective strategies for treatment of acute ischemic stroke, Huntington's disease, Parkinson's disease, and Alzheimer's disease. In all these chapters the authors review the current mechanismof treatment as well as the latest research results. The book is well written, the quality of the illustrations is adequate, and the references are numerous and current. The index, however, is not sufficient. The book meets the needs of neuroscientists who want to have at their fingertips the latest research results.
Editorials
From The Critics
Reviewer: Gabriel Gonzalez-Portillo, MD(University of Illinois at Chicago College of Medicine)Description: In this volume of Contemporary Neuroscience, the authors (neuroscientists, industry-based pharmacologists, chemists, and clinicians) review the latest advances in the treatment of several neurological and psychiatric diseases.
Purpose: The purpose is to describe new advances in pharmacological treatment of diseases that are under intensive research. The authors achieve their objectives.
Audience: The book is directed at neuroscientists, neurologists, psychiatrists, neurosurgeons, and pharmacologists.
Features: The first three chapters are devoted to psychiatric diseases. In the first chapter there is a brief description of the etiology of schizophrenia, followed by an extensive review of the different sites of action (receptor subtypes) of antipsychotic drugs. The next chapter describes the transmembrane cellular signal transduction in affective disorders and, in the third chapter, the different mechanisms of action of drugs for anxiety and panic disorders are explained. In the next two chapters, the neurological manifestations of acute and chronic diseases and opioids and mechanism of pain are reviewed. In the former, the food intake suppression induced by immunomodulators is described as well as the potential pharmacological interventions; in the latter, the existence of multiple opioid receptors and the role of N-methyl-D-aspartate (NNMA) and nitric oxide systems in opioid tolerance are discussed. The remaining chapters are dedicated to specific neurological diseases that are under intensive research: epilepsy, neuroprotective strategies for treatment of acute ischemic stroke, Huntington's disease, Parkinson's disease, and Alzheimer's disease. In all these chapters the authors review the current mechanism of treatment as well as the latest research results. The book is well written, the quality of the illustrations is adequate, and the references are numerous and current. The index, however, is not sufficient.
Assessment: The book meets the needs of neuroscientists who want to have at their fingertips the latest research results.
From The Critics
Reviewer: Gabriel Gonzalez-Portillo, MD(University of Illinois at Chicago College of Medicine)Description: In this volume of Contemporary Neuroscience, the authors (neuroscientists, industry-based pharmacologists, chemists, and clinicians) review the latest advances in the treatment of several neurological and psychiatric diseases.
Purpose: The purpose is to describe new advances in pharmacological treatment of diseases that are under intensive research. The authors achieve their objectives.
Audience: The book is directed at neuroscientists, neurologists, psychiatrists, neurosurgeons, and pharmacologists.
Features: The first three chapters are devoted to psychiatric diseases. In the first chapter there is a brief description of the etiology of schizophrenia, followed by an extensive review of the different sites of action (receptor subtypes) of antipsychotic drugs. The next chapter describes the transmembrane cellular signal transduction in affective disorders and, in the third chapter, the different mechanisms of action of drugs for anxiety and panic disorders are explained. In the next two chapters, the neurological manifestations of acute and chronic diseases and opioids and mechanism of pain are reviewed. In the former, the food intake suppression induced by immunomodulators is described as well as the potential pharmacological interventions; in the latter, the existence of multiple opioid receptors and the role of N-methyl-D-aspartate (NNMA) and nitric oxide systems in opioid tolerance are discussed. The remaining chapters are dedicated to specific neurological diseases that are under intensive research: epilepsy, neuroprotective strategies for treatment of acute ischemic stroke, Huntington's disease, Parkinson's disease, and Alzheimer's disease. In all these chapters the authors review the current mechanism of treatment as well as the latest research results. The book is well written, the quality of the illustrations is adequate, and the references are numerous and current. The index, however, is not sufficient.
Assessment: The book meets the needs of neuroscientists who want to have at their fingertips the latest research results.
Gabriel Gonzalez-Portillo
In this volume of Contemporary Neuroscience, the authors (neuroscientists, industry-based pharmacologists, chemists, and clinicians) review the latest advances in the treatment of several neurological and psychiatric diseases. The purpose is to describe new advances in pharmacological treatment of diseases that are under intensive research. The authors achieve their objectives. The book is directed at neuroscientists, neurologists, psychiatrists, neurosurgeons, and pharmacologists. The first three chapters are devoted to psychiatric diseases. In the first chapter there is a brief description of the etiology of schizophrenia, followed by an extensive review of the different sites of action (receptor subtypes) of antipsychotic drugs. The next chapter describes the transmembrane cellular signal transduction in affective disorders and, in the third chapter, the different mechanisms of action of drugs for anxiety and panic disorders are explained. In the next two chapters, the neurological manifestations of acute and chronic diseases and opioids and mechanism of pain are reviewed. In the former, the food intake suppression induced by immunomodulators is described as well as the potential pharmacological interventions; in the latter, the existence of multiple opioid receptors and the role of N-methyl-D-aspartate (NNMA) and nitric oxide systems in opioid tolerance are discussed. The remaining chapters are dedicated to specific neurological diseases that are under intensive research: epilepsy, neuroprotective strategies for treatment of acute ischemic stroke, Huntington's disease, Parkinson's disease, and Alzheimer's disease. In all these chapters the authors review the current mechanismof treatment as well as the latest research results. The book is well written, the quality of the illustrations is adequate, and the references are numerous and current. The index, however, is not sufficient. The book meets the needs of neuroscientists who want to have at their fingertips the latest research results.Booknews
Neuroscientists, clinicians, and industry-based pharmacologists and chemists review recent approaches for treating diseases of the central nervous system, including affective disorders, Alzheimer's disease, Parkinson's disease, schizophrenia, anxiety, panic disorders, stroke, epilepsy, and Huntington's disease. They focus on developing rational strategies for drug design based on the new understanding of the underlying pathophysiology, and explore the potential for novel therapeutics from newly cloned receptor subtypes and from a developing understanding of signal transduction. Of interest to pharmacologists, neuroscientists, medicinal and synthetic chemists, physiologists, neurologists, and psychiatrists. Annotation c. Book News, Inc., Portland, OR (booknews.com)4 Stars! from Doody