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Overview
Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.
Synopsis
Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.Editorials
From The Critics
Reviewer: Hidayatullah G. Munshi, MD(Northwestern University)Description: Dr. Janusz Rak of the Henderson Research Center in Ontario, Canada has brought together a number of well-established researchers to show what is known about oncogenes and how this knowledge has helped to design targeted cancer therapies.
Purpose: The book describes clearly that the knowledge gained from understanding the basic biology of oncogenes has shaped how we treat cancer and has resulted in the development of a number of compounds that have been successfully used in clinical trials.
Audience: This book will be useful to anyone interested in the biology of cancer and how the basic knowledge gained from many years of effort could be translated into practical treatments. Thus, this book will be useful not only to those just starting their research careers, including graduate and medical students, but also to those who have been involved in the field of cancer biology and treatment for a number of years, including seasoned scientists and clinicians.
Features: The book is divided into three parts. The first part covers the basic concepts in oncogene research, including signal transduction networks. The second part details how oncogenes are important in tumor maintenance, angiogenesis, and metastasis. The last third of the book describes in detail compounds developed with this increased knowledge and understanding that are currently being used in clinical trials or already approved by the government.
Assessment: This is a well referenced and up-to-date book that will give the reader a taste of the excitement and revolution currently underway in the treatment of cancer with the use of targeted therapies.