Oxygen, Gene Expression, and Cellular Function

From The Critics

Reviewer: Frederick E. Samson, DO, PhD(University of Kansas Medical Center)
Description: This book covers a wide range of toxic and normal regulatory functions of reactive oxygen species (ROS). The editors bring together in one volume articles by authorities on the role of ROSs (reactive oxygen intermediates, oxygen free radicals) in cell development, cell functions, cytotoxicity, carcinogenesis, aging, and in signal transduction of gene expression. The chapters are chiefly position papers or surveys on pertinent concepts. Although the book is Volume 105 in the Lung Biology in Health and Disease series, most of the text is relevant to other organs.
Purpose: The purpose was to have experts write about the fascinating, rich complexity of the interactions of oxygen metabolites with other molecules and cells and their importance in biology, medicine, health, and disease. The book is timely and relevant to the extensive current interest in antioxidants, nutrition, free radicals, cancer, genes, and the aging process.
Audience: This volume is useful for a wide range of scientists, including graduate students and postdoctoral fellows in chemical biology, molecular genetics, cell biology, biomedical science, nutrition, and to some extent, clinical residents, academic physicians, and specialists in pulmonary medicine.
Features: This is an attractive, manageable, volume with extensive up-to-date references, including full titles, a fairly complete index, and a list of every name in the bibliography with page numbers. It is a tutorial as well as a text on advances and future directions in a topic relevant to many aspects of health and disease.
Assessment: The abundance of edited volumes and the exponential increase in journal articles and news releases on oxygen free radicals make this book, with its clear overviews and expositions of the major concepts, especially useful.

Frederick E. Samson

This book covers a wide range of toxic and normal regulatory functions of reactive oxygen species (ROS). The editors bring together in one volume articles by authorities on the role of ROSs (reactive oxygen intermediates, oxygen free radicals) in cell development, cell functions, cytotoxicity, carcinogenesis, aging, and in signal transduction of gene expression. The chapters are chiefly position papers or surveys on pertinent concepts. Although the book is Volume 105 in the Lung Biology in Health and Disease series, most of the text is relevant to other organs. The purpose was to have experts write about the fascinating, rich complexity of the interactions of oxygen metabolites with other molecules and cells and their importance in biology, medicine, health, and disease. The book is timely and relevant to the extensive current interest in antioxidants, nutrition, free radicals, cancer, genes, and the aging process. This volume is useful for a wide range of scientists, including graduate students and postdoctoral fellows in chemical biology, molecular genetics, cell biology, biomedical science, nutrition, and to some extent, clinical residents, academic physicians, and specialists in pulmonary medicine. This is an attractive, manageable, volume with extensive up-to-date references, including full titles, a fairly complete index, and a list of every name in the bibliography with page numbers. It is a tutorial as well as a text on advances and future directions in a topic relevant to many aspects of health and disease. The abundance of edited volumes and the exponential increase in journal articles and news releases on oxygen free radicals make this book, with its clear overviews andexpositions of the major concepts, especially useful.

Free Radical Research

...an up-to-date review...of current understanding of the cellular and molecular response to excess oxygen...a valuable source.

Booknews

Examines an array of topics relating to the role of oxygen in various diseases and conditions in humans and its impact on evolution and ontogeny. Draws heavily on molecular biology and incorporates current views of reactive oxygen species, mechanisms evolved by cells to withstand their toxic effects, and their role in physiologically relevant conditions of oxidative stress. Among the topics are cellular sources and steady-state levels of reactive oxygen species, lessons from permanent cell lines regarding metabolic effects of hyperoxia, oxidative stress and cell proliferation, oxygen control of erythropoietin gene expression, the role of antioxidant enzymes in the cancer phenotype, and lung antioxidant enzyme gene expression and tolerance to hyperoxia. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody