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Overview
During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families.This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.
The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.
The book contains predominantly black-and-white illustrations, with some color illustrations.
Synopsis
Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.
Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Ben Zion Roitberg
This is Volume 16 of the Handbook of Clinical Neuroanatomy Series. The editors present reviews on the brain localization and function of ten different neuropeptide receptors. The purpose is to update and expand the information presented in a 1992 monograph on neuropeptide receptors in the same series. As the advances in this important field have been extensive, this update is timely. The editors present thorough reviews and fulfill their objective. However, for a complete review of peptide receptors in the brain, Part II (Volume 17) should also be read. Although the editors do not state the intended audience, a monograph of this type is clearly directed at neuroscientists working on diverse projects ranging from understanding basic cellular processes to the study of neuroregeneration and transplantation. The editors are prominent figures and leaders in neuroscience. The editors chose to concentrate on ten neuropeptide receptor systems in this volume. The reviews are thorough and there are high quality illustrations and extensive reference lists. The structure of the reviews is uniform, and the articles are written uniformly well. This reflects not only on the contributors, but also suggests excellent editorial work. This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms.
Editorials
From The Critics
Reviewer: Ben Zion Roitberg, MD(University of Illinois at Chicago College of Medicine)Description: This is Volume 16 of the Handbook of Clinical Neuroanatomy Series. The editors present reviews on the brain localization and function of ten different neuropeptide receptors.
Purpose: The purpose is to update and expand the information presented in a 1992 monograph on neuropeptide receptors in the same series. As the advances in this important field have been extensive, this update is timely. The editors present thorough reviews and fulfill their objective. However, for a complete review of peptide receptors in the brain, Part II (Volume 17) should also be read.
Audience: Although the editors do not state the intended audience, a monograph of this type is clearly directed at neuroscientists working on diverse projects ranging from understanding basic cellular processes to the study of neuroregeneration and transplantation. The editors are prominent figures and leaders in neuroscience.
Features: The editors chose to concentrate on ten neuropeptide receptor systems in this volume. The reviews are thorough and there are high quality illustrations and extensive reference lists. The structure of the reviews is uniform, and the articles are written uniformly well. This reflects not only on the contributors, but also suggests excellent editorial work.
Assessment: This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms.
From the Publisher
(B.Z. Roitberg, University of Illinois at Chicago College of Medicine)This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms.
Doody's
From The Critics
Reviewer: Ben Zion Roitberg, MD(University of Illinois at Chicago College of Medicine)Description: This is Volume 16 of the Handbook of Clinical Neuroanatomy Series. The editors present reviews on the brain localization and function of ten different neuropeptide receptors.
Purpose: The purpose is to update and expand the information presented in a 1992 monograph on neuropeptide receptors in the same series. As the advances in this important field have been extensive, this update is timely. The editors present thorough reviews and fulfill their objective. However, for a complete review of peptide receptors in the brain, Part II (Volume 17) should also be read.
Audience: Although the editors do not state the intended audience, a monograph of this type is clearly directed at neuroscientists working on diverse projects ranging from understanding basic cellular processes to the study of neuroregeneration and transplantation. The editors are prominent figures and leaders in neuroscience.
Features: The editors chose to concentrate on ten neuropeptide receptor systems in this volume. The reviews are thorough and there are high quality illustrations and extensive reference lists. The structure of the reviews is uniform, and the articles are written uniformly well. This reflects not only on the contributors, but also suggests excellent editorial work.
Assessment: This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms.
Ben Zion Roitberg
This is Volume 16 of the Handbook of Clinical Neuroanatomy Series. The editors present reviews on the brain localization and function of ten different neuropeptide receptors. The purpose is to update and expand the information presented in a 1992 monograph on neuropeptide receptors in the same series. As the advances in this important field have been extensive, this update is timely. The editors present thorough reviews and fulfill their objective. However, for a complete review of peptide receptors in the brain, Part II (Volume 17) should also be read. Although the editors do not state the intended audience, a monograph of this type is clearly directed at neuroscientists working on diverse projects ranging from understanding basic cellular processes to the study of neuroregeneration and transplantation. The editors are prominent figures and leaders in neuroscience. The editors chose to concentrate on ten neuropeptide receptor systems in this volume. The reviews are thorough and there are high quality illustrations and extensive reference lists. The structure of the reviews is uniform, and the articles are written uniformly well. This reflects not only on the contributors, but also suggests excellent editorial work. This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms.4 Stars! from Doody