Overview
Principles and Practice of Bioanalysis provides a guide to the methods available and the techniques currently used in this field. It provides up to the minute information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The authors writes in an informal and didactic style, offering a logical path through the problems of small molecule (bio)analysis and enables readers to choose appropriate methods of analysis for their needs. Principles and Practice of Bioanalysis provides an overview of analytical methods for analytical scientists within the pharmaceutical industry, research and development, the agrochemical industry, and scientists in the health service, biology and biochemistry. It also gives postgraduate students a useful reference for their research methods.
The book contains black-and-white illustrations.
Synopsis
Principles and Practice of Bioanalysis provides a guide to the methods available and the techniques currently used in this field. It provides up to the minute information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The authors writes in an informal and didactic style, offering a logical path through the problems of small molecule (bio)analysis and enables readers to choose appropriate methods of analysis for their needs. Principles and Practice of Bioanalysis provides an overview of analytical methods for analytical scientists within the pharmaceutical industry, research and development, the agrochemical industry, and scientists in the health service, biology and biochemistry. It also gives postgraduate students a useful reference for their research methods.
Doody Review Services
Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description:This is an introduction to practical, analytical methods used in the pharmacology industry.
Purpose:This book is intended to serve as a text for a course in analysis developed by the pharmaceutical industry. This goal is well reflected in the nature of the material covered and the emphases.
Audience:Students needing an appreciation of the analytical challenges faced by pharmaceutical manufacturing will profit from this text.
Features:An introductory chapter covers a set of drugs and their metabolites - the focus is mainly on ionization and solubility properties and does not cover modes of drug metabolism. Examples are provided but the relationship of chemical or physical properties to a given separation or analytical method is missing. A detailed discussion of HPLC follows that includes theory and detectors. Similar coverage of thin layer and gas-liquid chromatography and capillary electrophoresis completes the discussion of separation methods. The remainder is devoted to analytical methods, including immunoassays, mass spectrometry and NMR. Since no protocols are included, it can be assumed that the companion course does not include practical exercises.
Assessment:It should be realized that for most of the technologies discussed, only superficial treatment is provided. Conversely, if one needs mass spectral data in an industrial setting, the company will have experts available for that purpose.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This is an introduction to practical, analytical methods used in the pharmacology industry.
Purpose: This book is intended to serve as a text for a course in analysis developed by the pharmaceutical industry. This goal is well reflected in the nature of the material covered and the emphases.
Audience: Students needing an appreciation of the analytical challenges faced by pharmaceutical manufacturing will profit from this text.
Features: An introductory chapter covers a set of drugs and their metabolites - the focus is mainly on ionization and solubility properties and does not cover modes of drug metabolism. Examples are provided but the relationship of chemical or physical properties to a given separation or analytical method is missing. A detailed discussion of HPLC follows that includes theory and detectors. Similar coverage of thin layer and gas-liquid chromatography and capillary electrophoresis completes the discussion of separation methods. The remainder is devoted to analytical methods, including immunoassays, mass spectrometry and NMR. Since no protocols are included, it can be assumed that the companion course does not include practical exercises.
Assessment: It should be realized that for most of the technologies discussed, only superficial treatment is provided. Conversely, if one needs mass spectral data in an industrial setting, the company will have experts available for that purpose.
Booknews
Mostly British scientists working mostly in industry laboratories explain the methods and strategies for developing and running ultra- trace analysis for drugs, metabolites, and other substances. Rather than recipe-type guides, they describe the basics and strengths and weaknesses of such techniques as solid-phase extraction, high- performance liquid chromatography optimization, capillary electrophoresis, and immunoassays. Most of the examples are from the pharmaceutical industry, but the principles should apply to analyzing small molecules in a biomatrix in such fields as biochemistry and environmental monitoring as well. Annotation c. Book News, Inc., Portland, OR (booknews.com)2 Stars from Doody