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Overview
The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus.
Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include:
* Nuclear structure, replication, damage, and repair
* Regulation of gene expression
* The cell cycle
* Meiosis and recombination This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource.
Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.
Synopsis
The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus.
Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include:
* Nuclear structure, replication, damage, and repair
* Regulation of gene expression
* The cell cycle
* Meiosis and recombination
This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource.
Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.
Doody Review Services
Reviewer:Stephen A. Adam, PhD(Northwestern University Feinberg School of Medicine)
Description:This is a textbook-like treatment of the structural and functional relationships of activities within the cell nucleus.
Purpose:The author has two purposes: to promote the understanding that nuclear function goes hand-in-hand with nuclear architecture and to promote the idea that active polymerases are attached to discrete structures within nuclei. These ideas have been discussed for several years, but this book brings various bits of evidence together in a cogent argument for the reader to consider.
Audience:The book is written for students entering the field and those working in it who wish to put their results in this new structural context. It is an excellent introduction for students to nuclear architecture and function. Practitioners in the field may find useful those chapters dealing with areas with which they are less familiar. The author is an internationally recognized expert in this area and one of the originators of the idea of fixed polymerase complexes.
Features:The book covers all aspects of nuclear structure from the structure of nucleic acids to the three-dimensional organization of the nucleus. Particularly useful are side boxes that explain cellular processes and techniques in simple, easy to understand language. The illustrations clearly illuminate various mechanisms that occur in the nucleus that students often have difficulty conceptualizing. Each subsection in the chapters is based on seminal papers that provide the key points of the section. Summaries highlighting the important concepts end each chapter.
Assessment:This book would be very useful for graduate students or postgraduate students entering a field of study related to the nucleus. It could also serve as a fine textbook for a graduate course in nuclear structure and function. The only caveat to this book is that all of the ideas presented are not yet widely accepted in the scientific community.
Editorials
From The Critics
Reviewer: Stephen A. Adam, PhD(Northwestern University Feinberg School of Medicine)Description: This is a textbook-like treatment of the structural and functional relationships of activities within the cell nucleus.
Purpose: The author has two purposes: to promote the understanding that nuclear function goes hand-in-hand with nuclear architecture and to promote the idea that active polymerases are attached to discrete structures within nuclei. These ideas have been discussed for several years, but this book brings various bits of evidence together in a cogent argument for the reader to consider.
Audience: The book is written for students entering the field and those working in it who wish to put their results in this new structural context. It is an excellent introduction for students to nuclear architecture and function. Practitioners in the field may find useful those chapters dealing with areas with which they are less familiar. The author is an internationally recognized expert in this area and one of the originators of the idea of fixed polymerase complexes.
Features: The book covers all aspects of nuclear structure from the structure of nucleic acids to the three-dimensional organization of the nucleus. Particularly useful are side boxes that explain cellular processes and techniques in simple, easy to understand language. The illustrations clearly illuminate various mechanisms that occur in the nucleus that students often have difficulty conceptualizing. Each subsection in the chapters is based on seminal papers that provide the key points of the section. Summaries highlighting the important concepts end each chapter.
Assessment: This book would be very useful for graduate students or postgraduate students entering a field of study related to the nucleus. It could also serve as a fine textbook for a graduate course in nuclear structure and function. The only caveat to this book is that all of the ideas presented are not yet widely accepted in the scientific community.
Booknews
For students entering his field and researchers working in it, Cook (cell biology, U. of Oxford) promotes the idea that the key players in the nucleus<-->the active polymerases<-->are attached to discrete structures within nuclei. He suggests readers put their own results into his newer structural context and decided whether the alternative provides a better approximation to the truth than the traditional one. He covers principles, structure, replication, transcription, repair, the regulation of gene expression, the cell cycle, and meiosis and recombination. Annotation c. Book News, Inc., Portland, OR (booknews.com)4 Stars! from Doody