Oncology, Radiology & Diagnostic Imaging, Immunology, Physics of Light - Spectrum Analysis, Medical & Biomedical Technology - General & Miscellaneous, Biochemistry - General & Miscellaneous, Biology - Biotechnology, Medical Technology, Biotechnology & Bio

Process Scale Purification of Antibodies

Name: Process Scale Purification of Antibodies
Author: Uwe Gottschalk
ISBN: 9781118210741

by Uwe Gottschalk (Editor)

Write a review

Overview

"Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Traditional column chromatography dominates today's purification trains, and many of the productivity gains rely on upscaling such devices. This comes with a cost penalty, however, and further increases in upstream productivity make it a challenge to keep downstream processing manageable. Advances in purification technology are urgently needed to meet the requirements of the marketplace without sacrificing product quality." Process Scale Purification of Antibodies offers scientists, researchers, and engineers an essential resource that focuses on current best practice in the manufacturing of antibody drugs, addresses problems in antibody purification, and offers suggestions to overcome current challenges and limitations. Written by experts in the field, the book examines old and new separation methods and includes an analysis of innovative trends that can help meet the economic pressures and escalating demand for antibody drugs.

About the Author, Uwe Gottschalk

Uwe Gottschalk, PhD, is Group Vice President, Purification Technologies, at Sartorius Stedim Biotech. Previously, he worked for Bayer Health Care, overseeing the purification of monoclonal antibodies and recombinant proteins produced in various expression systems. Dr. Gottschalk received a doctorate in chemistry from the University of Münster. He lectures at the University of Duisburg-Essen and the EPFL in Lausanne, Switzerland and has written extensively in the areas of biotechnology and somatic gene therapy.