Rats, Lice and History

When Rats, Lice and History appeared in 1935, Hans Zinsser was a highly regarded Harvard biologist who had never written about historical events. Although he had published under a pseudonym, virtually all of his previous writings had dealt with infections and immunity and had appeared either in medical and scientific journals or in book format. Today he is best remembered as the author of Rats, Lice, and History, which gone through multiple editions and remains a masterpiece of science writing for a general readership.

To Zinsser, scientific research was high adventure and the investigation of infectious disease, a field of battle. Yet at the same time he maintained a love of literature and philosophy. His goal in Rats, Lice and History was to bring science, philosophy, and literature together to establish the importance of disease, and especially epidemic infectious disease, as a major force in human affairs. Zinsser cast his work as the "biography" of a disease. In his view, infectious disease simply represented an attempt of a living organism to survive. From a human perspective, an invading pathogen was abnormal; from the perspective of the pathogen it was perfectly normal.

This book is devoted to a discussion of the biology of typhus and history of typhus fever in human affairs. Zinsser begins by pointing out that the louse was the constant companion of human beings. Under certain conditions–to wash or to change clothing–lice proliferated. The typhus pathogen was transmitted by rat fleas to human beings, who then transmitted it to other humans and in some strains from human to human.

Rats, Lice and History is a tour de force. It combines Zinsser's expertise in biology with his broad knowledge of the humanities

When Rats, Lice and History appeared in 1935, Hans Zinsser was a highly regarded Harvard biologist who had never written about historical events. Although he had published under a pseudonym, virtually all of his previous writings had dealt with infections and immunity and had appeared either in medical and scientific journals or in book format. Today he is best remembered as the author of Rats, Lice and History, which gone through multiple editions and remains a masterpiece of science writing for a general readership.

To Zinsser, scientific research was high adventure and the investigation of infectious disease, a field of battle. Yet at the same time he maintained a love of literature and philosophy. His goal in Rats, Lice and History was to bring science, philosophy, and literature together to establish the importance of disease, and especially epidemic infectious disease, as a major force in human affairs. Zinsser cast his work as the "biography" of a disease. In his view, infectious disease simply represented an attempt of a living organism to survive. From a human perspective, an invading pathogen was abnormal; from the perspective of the pathogen it was perfectly normal.

This book is devoted to a discussion of the biology of typhus and history of typhus fever in human affairs. Zinsser begins by pointing out that the louse was the constant companion of human beings. Under certain conditions-failure to wash or to change clothing-lice proliferated. The typhus pathogen was transmitted by rat fleas to human beings, who then transmitted it to other humans and in some strains from human to human. Rats, Lice and History is a tour de force. It combines Zinsser's expertise in biologywith his broad knowledge of the humanities.

About the Author:
Hans Zinsser (1878-1940) was an instructor of bacteriology at Columbia University

Hans Zinsser (1878-1940) received his doctorate at Columbia University and also was an instructor of bacteriology at Columbia University. Throughout his career he was also a professor at Stanford University as well as Harvard University. His scientific work focused on bacteriology and immunology and he is greatly associated with Brill's disease as well as typhus.

Gerald N. Grob is the Henry E. Sigerist Professor of the History of Medicine (emeritus) at Rutgers University. He is an elected member of the Institute of Medicine of the National Academy of Sciences and has been the president of the American Association for the History of Medicine. He is the author of The Deadly Truth: A History of Disease in America and, most recently, (with Howard H. Goldman) The Dilemma of Federal Mental Health Policy: Radical Reform or Incremental Change?