Botany - Morphological & Physiological, Biology - Molecular Biology, Botany - General & Miscellaneous, Botany - Diseases, Parasites, & Foreign Substances, Agricultural Diseases & Pests

Recombinant Antibodies

Name: Recombinant Antibodies
Author: Karen Harper
ISBN: 9780748407637

by Harper, Karen, Ziegler, Angelika

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Overview

The first part of this book combines basic information on antigens and antibodies with a review of technologies for both the development of recombinant antibodies and their application. The principles involved in producing recombinant antibodies from either pre-existing monoclonal antibodies or from phage display libraries are introduced with practical examples. Modern methods for the analysis of antibody binding properties are described in detail. Examples are given in the second part of this book for the application of recombinant antibody technology to antibody-mediated resistance to plant disease and immunomodulation of plant antigens. The potential of antibody-expressing plants as bioreactors for large-scale production and storage of recombinant antibodies is described and a future outlook given.

Presents various methodologies for production & analysis; diagnostic & other applications of scFc; future research.

About the Author, Karen Harper

Karen Harper

Karen Harper is a New York Times- and USA Today- bestselling author whose novels, both historical and contemporary, have been published worldwide. A former college and high school English instructor, Harper frequently travels to promote her books and speak about writing.

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Editorials

Booknews

For graduates and senior undergraduates in plant science or pathology or biotechnology, the two research scientists at the Scottish Crop Research Institute in Dundee describe all the techniques required to produce such antibodies and to apply them to plants. Following an introduction to the concepts of antibody-antigen binding, they explain methods for cloning and selecting single chain variable fragments and dedicated vectors for expressing them in bacteria for diagnostic purposes. Then they move on to other applications besides diagnosis, such as developing virus-resistant lines, creating plants with altered metabolism, and using plants as bioreactors to produce and store recombinant antibodies. Annotation c. Book News, Inc., Portland, OR (booknews.com)