Red Blood Cell Substitutes: Basic Principles and Applications

Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.

The book contains black-and-white illustrations.

Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.

M. Geno Tellez

This book is a general yet comprehensive overview of historic and contemporary issues and research in red blood cell substitutes. It is intended to provide a comprehensive overview of current strategic fundamental programs and clinical development of red blood cell substitutes. This is a worthy objective and the book meets the editors' objectives. There is not a specified target audience, but I believe it would include practitioners who frequently confront issues of red blood cell transfusions. The editors and contributors are experts in their respective fields. Graphs of data are frequently busy but user friendly. Tables summarizing information would make the narrative easier to follow. A glossary would be helpful to define new terminology. The content is extremely timely and comprehensive. The fundamentals of cardiovascular and pulmonary physiology are explained comprehensively. The references are surprisingly current. I recommend this as an up-to-date reference for a medical library and those who encounter RBC transfusion on a frequent basis.

Rudolph, Alan S., PhD, MD (Naval Research Laboratory); Rabinovici, Reuven, MD (Jefferson Medical Coll of Thomas Jefferson Univ); Feuerstein, Giora Z., MD, MSc (SmithKline Beecham Pharmaceuticals)

The contributors represent the specialties of surgery, anatomy, cell biology, injury science, bioengineering, physiology, biotechnology, and radiology. Most are from universities, research institutes, and pharmaceutical companies in the U.S. and Canada. Institutions prominently represented include Hemosol, Inc, in Ontario, Univ of Medicine and Dentistry of New Jersey, Brown, Univ of Illinois, UCSD, and UCSF.