Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Disease

Methodology and applications of redox proteomics

The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:
* The role of oxidized proteins in various disorders
* Pioneering studies on the development of redox proteomics
* Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
* The response and regulation of protein oxidation in different cell types
* The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease

Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Methodology and applications of redox proteomics



The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.

Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including:
* The role of oxidized proteins in various disorders
* Pioneering studies on the development of redox proteomics
* Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications
* The response and regulation of protein oxidation in different cell types
* The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease


Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Doody Review Services

Reviewer:Alan Cahill, Ph.D.(Thomas Jefferson University)
Description:Redox proteomics is the branch of proteomics that identifies oxidatively modified proteins in order to gain insights into normal and abnormal functions of cells. Oxidative modifications of proteins accompany aging and are seen in many disease states. Since oxidative modifications inhibit protein function, the authors contend that identifying oxidatively modified proteins will provide essential insights into the molecular pathways of human disease. This book includes 27 chapters on topics ranging from "modification of proteins by reactive oxygen species" to "oxidation of artery wall proteins by myeloperoxidase." It is divided into three parts: part I describes chemical processes involved in the oxidation of proteins; part II covers redox proteomics in normal cell physiology and pharmacology; and part III describes applications of redox proteomics to various disease states. The focus of this book is on chemistry and cellular biochemistry.
Purpose:According to the editors, the aim of this book is to "provide researchers with new insights into normal and altered physiology, and molecular mechanisms of disease...and provide a core reference text for experts in cellular physiology and proteomics." The editors also believe that this book could serve as a basis for a graduate-level course in proteomics.
Audience:The book is written for research scientists interested in proteomics and oxidative metabolism or proteins. Clinicians interested in neurodegenerative diseases will also find this topic (redox proteomics) particularly fascinating and relevant to their field of study. Students and laboratory staff will appreciate the depth of focus and extensive lists of references. It provides a gateway to this new and exciting field and is written by leading experts for a wide audience interested in chemistry and biochemistry.
Features:This book provides an extensive collection of state-of-the-art redox proteomics methodologies, and serves as an informative guide to cellular mechanisms of protein oxidation. Each chapter provides an introduction, conclusion, and helpful list of abbreviations. The black/white illustrations and line drawings are well done. A key feature is the invaluable collection of references, which cover all aspects of oxidative protein modification. The final set of chapters make a convincing case for the important role of oxidative stress in the pathogenesis of a number of disease states.
Assessment:This is a very informative resource that is sure to draw attention to oxidative damage as a key mediator of disease and aging. This book provides detailed and extremely informative insights into cellular mechanisms of protein oxidation. It illustrates how state-of-the-art redox proteomics can be used to identify oxidatively-modified proteins in a number of specific disease states. Its extensive collection of references and expertise makes it an invaluable resource for established scientists, students, and laboratory personnel alike. Every laboratory that uses redox proteomics in both clinical and academic research should possess a copy of this excellent book.

ISABELLA DALLE-DONNE, PHD, is Assistant Professor in the Department of Biology at the University of Milan, Italy. She has a PhD in cellular and molecular biology from the University of Milan.

ANDREA SCALONI, PHD, is First Investigator at the Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council in Naples, Italy. He received his PhD in chemical sciences from the University of Rome "La Sapienza" in Italy.

D. ALLAN BUTTERFIELD, PHD, is Alumni Professor of Chemistry and Director of the University of Kentucky Center of Membrane Sciences in Lexington, Kentucky, USA. He received his PhD in physical chemistry from Duke University.