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Overview
Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.
Synopsis
Genetics Institute, Inc., Cambridge, Massachusetts. Pharmaceutical Biotechnology, Volume 3. Second part of two-part set. Deals with in vivo degradation and methods designed to enhance protein stability.
Booknews
See preceding entry. Part B begins with degradation pathways that occur in vivo--of major concern during protein synthesis in cells, during their isolation and purification, and during their use in organisms. Finally, the volume includes a discussion of methods designed to enhance protein stability in order to obtain a more useful and beneficial therapeutic agent. The techniques include altering the primary structure of the protein through site-directed mutagenesis to produce a more stable protein entity. Stabilization attained through proper formulation of the protein or by a variety of chemical modifications is described in detail as well. Annotation c. Book News, Inc., Portland, OR (booknews.com)