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Overview
Extensively reorganized and revised with the latest data from this rapidly changing field, Lewin's Essential GENES, Third Edition, provides students with a comprehensive overview of molecular biology and molecular genetics. The authors took care to carefully modify the chapter order in an effort to provide a more clear and student-friendly presentation of course material. Chapter material has been updated throughout, including a completely revised chapter on regulatory RNA, to keep pace with this advancing field. The Third Editions exceptional pedagogy enhances student learning and helps readers understand and retain key material like never before. Concept and Reasoning Checks at the end of each chapter section, End-of-Chapter Questions and Further Readings sections, as well as several categories of special topics boxes, expand and reinforce important concepts.
Synopsis
Extensively reorganized and revised with the latest data from this rapidly changing field, Lewin's Essential GENES, Third Edition, provides students with a comprehensive overview of molecular biology and molecular genetics. The authors took care to carefully modify the chapter order in an effort to provide a more clear and student-friendly presentation of course material. Chapter material has been updated throughout, including a completely revised chapter on regulatory RNA, to keep pace with this advancing field. The Third Editions exceptional pedagogy enhances student learning and helps readers understand and retain key material like never before. Concept and Reasoning Checks at the end of each chapter section, End-of-Chapter Questions and Further Readings sections, as well as several categories of special topics boxes, expand and reinforce important concepts.Editorials
From The Critics
Reviewer: Omer Iqbal, MD, FACC, FESC(Loyola University Medical Center)Description: This is the third edition of a comprehensive overview of molecular biology and molecular genetics with an updated chapter on regulatory RNA and completely reorganized chapters on replication. Although the second edition was published in 2010, given the rapid strides in this field, this is a needed and welcome update.
Purpose: The purpose is to provide a clear and concise overview of the field for undergraduate students and for medical courses on the subject.
Audience: All undergraduate students and medical and other graduate students interested in the fields of molecular biology and molecular genetics will find this book extremely useful.
Features: The book is divided into four parts. The 10 chapters in part I include an introduction to the structure and function of DNA and cover DNA replication, gene expression, molecular laboratory techniques, interrupted structures of eukaryotic genes, genome structure and evolution, the structure of viral, prokaryotic and eukaryotic chromosomes, and the detailed structure of eukaryotic chromatin. Part II on DNA replication and recombination covers topics such as DNA replication in plasmids, viruses, prokaryotic and eukaryotic cells. Other chapters cover recombination and its role in DNA repair and the human immune system with detailed accounts of DNA repair pathways and transposable elements. Part III, on gene expression, covers bacterial and eukaryotic transcription, mRNA, RNA stability and localization, RNA processing, and catalytic roles of RNA. The final part covers topics such as regulation of bacterial gene expression via operons, regulation of gene expression during phage development as they infect bacterial cells, and eukaryotic gene regulation, including epigenetic modification. A concluding chapter details RNA-based control of gene expression in prokaryotes and eukaryotes. The book has several high quality illustrations, a very helpful glossary of terms, and a good index which students will find helpful.
Assessment: Given the rapid advances in the fields of molecular biology and molecular genetics, this third edition is justified.